CAS No.: 1019254-94-4

Purity: 98.38%

Target:

Research Areas:

Insulin levels modulator (Example 49) is an orally active insulin secretagogue. Insulin levels modulator can be used for the research of type 2 diabetes and type 2 diabetes-related disorders .

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MOTS-c (human)

1 Cited Publications

Cat. No.: HY-P2048

CAS No.: 1627580-64-6

Target:

Apoptosis GLUT AMPK

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

MOTS-c (human) is a mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

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MOTS-c(human) acetate

1 Cited Publications

Cat. No.: HY-P2048A

Target:

AMPK GLUT

Research Areas:

Neurological Disease Metabolic Disease

MOTS-c (human) acetate is a mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

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Insulin icodec

Cat. No.: HY-P4070

CAS No.: 1188379-43-2

Target:

Insulin Receptor

Research Areas:

Metabolic Disease

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

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Netoglitazone

Cat. No.: HY-100428

CAS No.: 161600-01-7

Purity: 99.88%

Synonyms: MCC-555; Isaglitazone

Target:

PPAR

Research Areas:

Metabolic Disease

Netoglitazone (MCC-555) is an orally active PPARγ ligand with an EC₅₀ of 8 μM. Netoglitazone mediates cell type-specific functional regulation, and modulates the transcriptional activity of PPARγ as a full agonist, partial agonist or antagonist. Netoglitazone induces adipogenesis, inhibits osteoblastogenesis, alters the weight of extramedullary fat depots and enhances insulin sensitivity. Netoglitazone reduces blood glucose levels. Netoglitazone can be used in research related to type 2 diabetes and non-insulin-dependent diabetes mellitus .

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D-Threitol

Cat. No.: HY-W012846

CAS No.: 2418-52-2

Category:

Other Diseases Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Saccharides

Target:

Endogenous Metabolite Glycosidase

D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC₅₀ of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle .

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GLP-1R modulator-1

Cat. No.: HY-171850

CAS No.: 2978244-71-0

Target:

GLP Receptor

Research Areas:

Metabolic Disease Inflammation/Immunology

GLP-1R modulator-1 (Compound 384) is an orally active, potent selective glucagon-like peptide-1 receptor (GLP-1R) agonist. GLP-1R modulator-1 activates G-protein coupled signaling, elevates intracellular cAMP levels, promotes insulin secretion, delays gastric emptying and suppresses appetite. GLP-1R modulator-1 is promising for research of type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH) .

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