83 Results for "

Isoquinoline

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "Isoquinoline" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-W012732
CAS No.: 119-65-3
Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities .
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23
23 Publications Verification
Cat. No.: HY-N0485
CAS No.: 5088-90-4
Liensinine Diperchlor​ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlor​ate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlor​ate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .
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20
20 Cited Publications
Cat. No.: HY-13764
CAS No.: 518-34-3
Purity:  99.90%
Synonyms: NSC-77037; d-Tetrandrine
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca 2+ current (ICa) and Ca 2+-activated K + current.
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17
17 Cited Publications
Cat. No.: HY-15477
CAS No.: 132836-42-1
Purity:  99.92%
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
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17
17 Cited Publications
Cat. No.: HY-15477A
CAS No.: 3028631-24-2
Purity:  99.71%
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
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5
5 Cited Publications
Cat. No.: HY-N2255
CAS No.: 25127-29-1
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na + current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .
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2
2 Cited Publications
Cat. No.: HY-N2369
CAS No.: 476-32-4
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .
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1
1 Cited Publications
Cat. No.: HY-N0923
CAS No.: 518-69-4
Synonyms: (+)-Corydaline; Corydalin
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .
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1
1 Cited Publications
Cat. No.: HY-N2003
CAS No.: 3520-14-7
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .
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1
1 Cited Publications
Cat. No.: HY-N3035
CAS No.: 38853-67-7
Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities .
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Cat. No.: HY-N1934
CAS No.: 483-15-8
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .
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Cat. No.: HY-N0793
CAS No.: 130-86-9
Synonyms: Corydinine
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .
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Cat. No.: HY-N0586
CAS No.: 23599-69-1
Synonyms: (+)-Laurelliptine
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .
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Cat. No.: HY-132828
CAS No.: 1639303-73-3
Synonyms: LT3001; DHDMIQK(KAP)
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .
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Cat. No.: HY-W206168
CAS No.: 16659-88-4
Synonyms: Norlaudanosoline hydrobromide
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [ 3H]DA uptake with a Ki of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction .
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Cat. No.: HY-N0586A
CAS No.: 5083-84-1
Synonyms: (+)-Laurelliptine hydrochloride
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .
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Cat. No.: HY-69055
CAS No.: 58794-09-5
7-Bromoisoquinoline is a brominated isoquinoline and synthetic precursor that constructs the isoquinoline functional group at the C17 position of target molecules. 7-Bromoisoquinoline serves as a key synthetic intermediate for the synthesis of cortistatin A-derived anti-angiogenic steroidal analogs (e.g., 7-tributylstannyl isoquinoline). 7-Bromoisoquinoline .
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Cat. No.: HY-N7512
CAS No.: 6871-21-2
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .
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Cat. No.: HY-N8420
CAS No.: 21796-15-6
Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .
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Cat. No.: HY-W012732S
CAS No.: 17157-12-9
Isoquinoline-d7 is the deuterium labeled Isoquinoline . Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .
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