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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
K1 strain
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "K1 strain" in MCE Product Catalog:
1
Category:
Infection Macrolide Antibiotics Antibiotics Anti-parasitic Microorganism Disease Research Antibacterial Disease Research Fields
Target:
Cat. No.: HY-N5109
CAS No.: 138664-32-1
Category:
Infection Alkaloids Plant Monophenols Phenols Other Families Extract Disease Research Fields Isoquinoline Alkaloids
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Infection Alkaloids Plant Quinoline Alkaloids Aconitum carmichaeli Debx. Extract Disease Research Fields Ranunculaceae Extract
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Cat. No.: HY-170219
CAS No.: 3113265-82-7
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Research Areas:
RMM23 is an inhibitor targeting PfBDP1 with a Kd value of 1.24 μM. RMM23 against the wild-type strains 3D7 and NF54, and the multidrug-resistant K1 strain in vitro blood stage, with EC50 values of 18 μM, 14 μM, 20 μM, respectively .
Cat. No.: HY-126640
CAS No.: 359844-69-2
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Target:
Cat. No.: HY-157892
CAS No.: 123580-46-1
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .
Cat. No.: HY-106515
CAS No.: 74129-03-6
Synonyms: WR228258
Tebuquine (WR228258), a 4-aminoquinoline, is a potent antimalarial agent. Tebuquine is active against the Chloroquine (HY-17589A) sensitive HB3 strain and the Chloroquine resistant K1 strain of Plasmodium falciparum with IC50s of 0.9 nM and 20.8 nM, respectively .
Cat. No.: HY-N10624
CAS No.: 2925302-01-6
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Target:
Category:
Alkaloids Piperidine Alkaloids Plant Menispermaceae Extract Triclisia gilletii (De Wild.) Staner Extract
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Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .
Cat. No.: HY-163765
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Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .
Cat. No.: HY-137985
CAS No.: 149598-70-9
Synonyms: Stachybotrydial; F 1839M; Stachybotrydial
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Research Areas:
Mer-NF5003F (Stachybotrydial; F 1839M), a sesquiterpene isolated from Stachybotrys, inhibits avian medulloblastoma virus (AMV) protease (IC50=7.8 μM). Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC50=0.61, 6.7, and 10 μg/mL, respectively), and fucosyltransferase (IC50=11.3 μg/mL). Mer-NF5003F has in vitro activity against herpes simplex virus HSV-1 (IC50=4.32 μg/mL) and multidrug-resistant Plasmodium falciparum K1 strain (IC50=0.85 μg/mL).
Cat. No.: HY-152233
CAS No.: 3038793-35-7
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC50 value of 0.053 μM for wild-type HIV-1 and an EC50 value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W413619
CAS No.: 1193314-24-7
Synonyms: NITD609 enantiomer; KAE609 enantiomer
Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria .
Cat. No.: HY-187926
CAS No.: 2675491-09-3
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Antimalarial agent 67 is an orally active inositol acyltransferase Gwt1p inhibitor and antimalarial agent, with IC50 values of 0.030 μM and 0.041 μM against P. falciparum 3D7 and K1 strains, respectively. Antimalarial agent 67 blocks inositol ring acylation by inhibiting the key enzyme Gwt1p in the GPI biosynthesis pathway of Plasmodium, thereby inhibiting parasite growth and maturation. Antimalarial agent 67 can be used for research on malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
