34 Results for "

K562/S

" in MedChemExpress (MCE) Product Catalog:
Products (34)

34 Results for "K562/S" in MCE Product Catalog:

82
Fingolimod hydrochloride
Fingolimod hydrochloride
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82 Publications Verification
Cat. No.: HY-12005
CAS No.: 162359-56-0
Purity:  99.95%
Synonyms: FTY720
Target:  

LPL Receptor PAK

Research Areas:  

Inflammation/Immunology Cancer

Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant .
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82
Fingolimod
Fingolimod
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82 Publications Verification
Cat. No.: HY-11063
CAS No.: 162359-55-9
Purity:  99.97%
Synonyms: FTY720 free base
Target:  

LPL Receptor PAK

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .
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6
AMPK-IN-3
AMPK-IN-3
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6 Cited Publications
Cat. No.: HY-151361
CAS No.: 2417674-27-0
Purity:  98.00%
Target:  

AMPK

Research Areas:  

Cancer

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer .
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1
N-Desmethyl imatinib
N-Desmethyl imatinib
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1 Cited Publications
Cat. No.: HY-G0017
CAS No.: 404844-02-6
Synonyms: Norimatinib; Imatinib metabolite N-Desmethyl imatinib; CGP 74588
Target:  

Drug Metabolite P-glycoprotein Apoptosis Bcr-Abl

Research Areas:  

Neurological Disease Cancer

N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .
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PD180970
PD180970
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Cat. No.: HY-103274
CAS No.: 287204-45-9
Purity:  99.27%
Target:  

Bcr-Abl Src c-Kit Apoptosis

Research Areas:  

Neurological Disease Cancer

PD180970 is a highly potent and ATP-competitive p210 Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210 Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research .
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EIF2α activator 2
EIF2α activator 2
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Cat. No.: HY-147832
CAS No.: 1501618-04-7
Purity:  99.88%
Target:  

Eukaryotic Initiation Factor (eIF)

Research Areas:  

Cancer

EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively .
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R-30-Hydroxygambogic acid
R-30-Hydroxygambogic acid
0 Images
Cat. No.: HY-N10678
CAS No.: 881027-35-6
Category:  

Ketones, Aldehydes, Acids Guttiferae Extract Plants 500 - Internal Server Error | MedChemExpress

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