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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
Keap1-Cul3 interaction
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "Keap1-Cul3 interaction" in MCE Product Catalog:
Cat. No.: HY-189812
CAS No.: 152243-63-5
Research Areas:
Keap1-Nrf2-IN-31 is a potent Keap1-Nrf2 interaction (PPI) inhibitor. Keap1-Nrf2-IN-31 binds with dual high affinity to the KDC (Kd = 1.2 μM (MST assay); Kd = 171 nM (SRP assay)) and BTB (Kd = 71 nM (MST assay); Kd = 74.1 nM (SRP assay)) domains of Keap1, inhibits the function of the Keap1-Cul3 complex and blocks the ubiquitination-mediated degradation of Nrf2, thereby promoting Nrf2 nuclear translocation and activating the expression of antioxidant genes. Keap1-Nrf2-IN-31 can be used for research on Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
