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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
L-type Ca2+ current
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "L-type Ca2+ current" in MCE Product Catalog:
15
15 Publications Verification
Cat. No.: HY-15553A
CAS No.: 116666-63-8
Synonyms: Ro 40-5967 dihydrochloride
Target:
Research Areas:
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca 2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .
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9 Cited Publications
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(S)-(-)-Bay-K-8644 is an agonist of L-type Ca 2+ channel. (S)-(-)-Bay-K-8644 activates Ba 2+ currents (IBa) (EC50=32 nM).
3
Category:
Cardiovascular Disease Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Indole Alkaloids Apocynaceae Extract
Target:
3
3 Cited Publications
Synonyms: (+)-3,4-Didehydrocoronaridine Tartrate
Category:
Cardiovascular Disease Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Cancer Indole Alkaloids Apocynaceae Extract
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Cancer
Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca 2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba 2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .
Cat. No.: HY-15553
CAS No.: 116644-53-2
Synonyms: Ro 40-5967
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Research Areas:
Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca 2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively .
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Research Areas:
UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca 2+ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K + channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias .
Cat. No.: HY-B0549
CAS No.: 15301-69-6
Synonyms: Rec-7-0040 free base; DW61 free base
Research Areas:
Flavoxate (Rec-7-0040 free base; DW61 free base) is an orally active L-type Ca 2+ channel inhibitor and antispasmodic. Flavoxate inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba 2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate can be used in research on overactive bladder and related voiding dysfunctions .
Cat. No.: HY-B0549AR
CAS No.: 3717-88-2
Synonyms: Rec-7-0040 (Standard); DW61 (Standard)
Target:
Reference Standards mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor
Research Areas:
Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca 2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba 2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .
Cat. No.: HY-116540A
CAS No.: 115116-37-5
Synonyms: 7DMB-Forskolin
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Research Areas:
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg 2+-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca 2+ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .
Cat. No.: HY-116500A
CAS No.: 228123-15-7
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AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
Category:
Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Indole Alkaloids Apocynaceae Extract
Target:
Cat. No.: HY-N0252B
CAS No.: 153230-94-5
Synonyms: (+)-3,4-Didehydrocoronaridine Sulfate
Category:
Cardiovascular Disease Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Indole Alkaloids Apocynaceae Extract
Target:
Cat. No.: HY-116540
CAS No.: 110452-75-0
Synonyms: 7DMB-Forskolin free base
Target:
Research Areas:
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg 2+-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca 2+ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .
Cat. No.: HY-W040171S
CAS No.: 2714419-98-2
Tefluthrin-d5 is the deuterated-labeled Tefluthrin (HY-W040171). Tefluthrin is a pyrethroid insecticide with developmental toxicity. Tefluthrin modifies the Nav1.6 voltage-gated sodium channel, prolonging Nav1.6 channel inactivation and deactivation in HEK293 cells . Tefluthrin reduces L-type Ca 2+ currents, inhibits K + outward currents, and enhances spontaneous/oscillatory action currents. Tefluthrin induces oxidative stress in rat models, causing damage to blood, immune, and nucleic acid metabolism, chromosomal aberrations, and sperm malformations; it induces oxidative stress and p53‑caspase‑3 pathway apoptosis in zebrafish models, leading to cardiac-skeletal developmental malformations such as pericardial edema, spinal curvature, and decreased skeletal mineralization. Tefluthrin can be used for pest control and research on diseases such as neurodegenerative diseases .
Cat. No.: HY-B0549S
CAS No.: 2748541-85-5
Cat. No.: HY-B0549AS
CAS No.: 1189678-43-0
Cat. No.: HY-187014
CAS No.: 141360-03-4
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Research Areas:
NNC 09-0026 is a neuronal calcium channel inhibitor. NNC 09-0026 exhibits IC50 values of 10 μM and 13 μM against neuronal L-type voltage-gated calcium channels, and an IC50 value of 13 μM against rat neuronal N-type voltage-gated calcium channels, with higher selectivity for neuronal L-type channels over peripheral L-type channels. NNC 09-0026 inhibits voltage-dependent Ca 2+ channel currents, blocks Ca 2+ influx through neuronal L-type and N-type voltage-gated calcium channels, and reduces potassium-stimulated calcium uptake in rat cerebral cortex synaptosomes. NNC 09-0026 inhibits TTX-sensitive Na + channel currents in rat cerebellar Purkinje neurons. NNC 09-0026 attenuates ischemia-induced neuronal death, infarct volume and neurological deficits in rat models of cerebral ischemia. NNC 09-0026 can be used for studies on global cerebral ischemia, focal ischemia and cerebral ischemia-related research .
Cat. No.: HY-W040171
CAS No.: 79538-32-2
Research Areas:
Tefluthrin is a pyrethroid insecticide with developmental toxicity. Tefluthrin modifies the Nav1.6 voltage-gated sodium channel, prolonging Nav1.6 channel inactivation and deactivation in HEK293 cells . Tefluthrin reduces L-type Ca 2+ currents, inhibits K + outward currents, and enhances spontaneous/oscillatory action currents. Tefluthrin induces oxidative stress in rat models, causing damage to blood, immune, and nucleic acid metabolism, chromosomal aberrations, and sperm malformations; it induces oxidative stress and p53‑caspase‑3 pathway apoptosis in zebrafish models, leading to cardiac-skeletal developmental malformations such as pericardial edema, spinal curvature, and decreased skeletal mineralization. Tefluthrin can be used for pest control and research on diseases such as neurodegenerative diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
