47

Apilimod

47 Cited Publications

Cat. No.: HY-14644

CAS No.: 541550-19-0

Purity: 99.80%

Synonyms: STA 5326; LAM-002A free base; AIT-101

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

47

Apilimod mesylate

47 Cited Publications

Cat. No.: HY-14644A

CAS No.: 870087-36-8

Purity: 99.83%

Synonyms: STA 5326 mesylate; LAM-002A; AIT-101 mesylate

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

(Rac)-Idroxioleic acid

Cat. No.: HY-129467

CAS No.: 56472-29-8

Purity: ≥98.0%

Synonyms: 2-Hydroxyoleic acid; 2-OHOA; LAM561

Target:

Apoptosis

Research Areas:

Inflammation/Immunology Cancer

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

306-N16B

Cat. No.: HY-150229

CAS No.: 2803699-70-7

Purity: 98.84%

Target:

Liposome

Research Areas:

Cancer

306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Niazimicin

Cat. No.: HY-N8503

CAS No.: 147821-49-6

Category:

Alkaloids Moringaceae Extract Other Alkaloids Moringa oleifera Lam. Plants

Target:

Others

Niazimicin can be isolated from seeds and leaves of Moringa oleifera Lam. Niazimicin is thiocarbamate compound .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6-Formyllimetin

Cat. No.: HY-N10842

CAS No.: 88140-31-2

Category:

Umbelliferae Extract Centella asiatica (L.) Urb. Coumarins Phenylpropanoids Plants

Target:

Others

6-Formyllimetin is a natural product isolated from the root bark of T. asiatica LAM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

(+)-6-(3-Chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin

Cat. No.: HY-N10803

CAS No.: 15575-50-5

Category:

Umbelliferae Extract Centella asiatica (L.) Urb. Coumarins Cucurbitaceae Extract Phenylpropanoids Plants Momordica charantia Linn.

Target:

Others

(+)-6-(3-Chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin is a nature product that could be isolated form the root bark of Toddalia asiatica (L.) LAM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5-InoAz

Cat. No.: HY-164915

CAS No.: 1218932-97-8

Target:

Bacterial

Research Areas:

Metabolic Disease

5-InoAz is an inositol analogue containing an azide group, which is used as a metabolic probe for labeling the mycobacterial cell envelope. 5-InoAz integrates into cell envelope glycolipids [phosphatidylinositol mannoside (PIM), PIM-anchored lipomannan (LM), and lipoarabinomannan (LAM)] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Niazirin

Cat. No.: HY-N9097

CAS No.: 122001-32-5

Category:

Moringaceae Extract Moringa oleifera Lam. Plants Saccharides Monosaccharides

Target:

Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase

Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

Compare

loading...