10

Pentamidine

10 Publications Verification

Cat. No.: HY-B0537

CAS No.: 100-33-4

Synonyms: MP-601205

Target:

Parasite Fungal Phosphatase Bacterial Antibiotic

Research Areas:

Infection Cancer

Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

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10

Pentamidine isethionate

10 Publications Verification

Cat. No.: HY-B0537B

CAS No.: 140-64-7

Synonyms: MP-601205 isethionate

Target:

Parasite Fungal Phosphatase Bacterial Antibiotic

Research Areas:

Infection Cancer

Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

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3

9-Amino-6-chloro-2-methoxyacridine

3 Cited Publications

Cat. No.: HY-118155

CAS No.: 3548-09-2

Purity: 99.56%

Synonyms: ACMA

Target:

Fluorescent Dye DNA/RNA Synthesis DNA Alkylator/Crosslinker Flavivirus

Research Areas:

Infection

9-Amino-6-chloro-2-methoxyacridine (ACMA) is an acridine derivative and Fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine inhibits viral replication, inhibits DNA synthesis and protein metabolism through cell cycle arrest, and induces lipid metabolism regulation, genotoxicity, mutagenicity, and cytotoxicity through DNA strand breaks. 9-Amino-6-chloro-2-methoxyacridine partially intercalates into DNA, forming three distinct complexes, stabilizes the DNA helix, and quenches fluorescence upon intercalation through electron transfer with guanine. 9-Amino-6-chloro-2-methoxyacridine monitors the generation and collapse of the proton motive force, H ⁺ pumping by F₁F₀-ATP synthase, and the collapse of pH gradients in inverted membrane vesicles. 9-Amino-6-chloro-2-methoxyacridine shows potent anti-BVDV activity. 9-Amino-6-chloro-2-methoxyacridine can be used for research on bovine viral diarrhea virus infection, leishmaniasis, and MRSA infection .

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1

Edelfosine

1 Cited Publications

Cat. No.: HY-108610A

CAS No.: 70641-51-9

Purity: ≥99.0%

Synonyms: ET-18-OCH3

Target:

Apoptosis Parasite Bcl-2 Family Cytochrome P450

Research Areas:

Infection Inflammation/Immunology Cancer

Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .

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1

Pam2CSK4 TFA

1 Cited Publications

Cat. No.: HY-P1181A

Target:

Toll-like Receptor (TLR) NO Synthase IKK Akt PKC NF-κB p38 MAPK Interleukin Related

Research Areas:

Cardiovascular Disease Infection Inflammation/Immunology Cancer

Pam2CSK4 TFA is a TLR2 agonist. Pam2CSK4 TFA induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 TFA activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 TFA expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 TFA acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 TFA can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis .

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N-(2-Hydroxypropyl)methacrylamide

Cat. No.: HY-W077028

CAS No.: 21442-01-3

Target:

Biochemical Assay Reagents

Research Areas:

Others

N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .

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Indotecan

Cat. No.: HY-18351

CAS No.: 915303-09-2

Synonyms: LMP-400; NSC-724998

Target:

Topoisomerase

Research Areas:

Infection Cancer

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC₅₀s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis .

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1H-pyrazole

Cat. No.: HY-76228

CAS No.: 288-13-1

Synonyms: Pyrazole

Target:

Parasite iGluR

Research Areas:

Infection

1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

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Galeflaprit

Cat. No.: HY-131350

CAS No.: 1799330-15-6

Purity: 99.08%

Synonyms: LXE408

Target:

Proteasome Parasite

Research Areas:

Infection Cancer

Galeflaprit (LXE408) is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. Galeflaprit has an IC₅₀ of 0.04 μM for L. donovani proteasome and an EC₅₀ of 0.04 μM for L. donovani. Galeflaprit has a low propensity to cross the blood brain barrier. Galeflaprit has the potential for visceral leishmaniasis (VL) research .

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trans-Aconitic acid

Cat. No.: HY-W016813

CAS No.: 4023-65-8

Category:

Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:

Parasite

trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .

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Aurachin D

Cat. No.: HY-N7151

CAS No.: 108354-13-8

Category:

Alkaloids Microorganisms Quinoline Alkaloids

Target:

Antibiotic Bacterial Fungal

Aurachin D is an antibiotic and selective cytochrome bd oxidase inhibitor. Aurachin D exhibits inhibitory effects against Gram-positive bacteria and a small number of fungi, with an IC₅₀ value of 0.1 μM against Escherichia coli and an IC₅₀ value ranging from 0.13 to 33 μM against Mycobacterium tuberculosis. Aurachin D binds to and inhibits cytochrome bd oxidase, thereby blocking the electron transfer process, disrupting the respiratory chain and energy metabolism of pathogens. Aurachin D can be used in research related to leishmaniasis, malaria, Chagas disease, African trypanosomiasis, and tuberculosis [2] .

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Dehydroemetine

Cat. No.: HY-121241

CAS No.: 4914-30-1

Purity: 99.90%

Target:

Parasite

Research Areas:

Infection

Dehydroemetine is an orally active antiparasitic agent. Dehydroemetine can inhibit parasites such as Entamoeba histolytica, and it can also be used in the research of parasitic diseases like visceral leishmaniasis .

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