48

Saracatinib

48 Publications Verification

Cat. No.: HY-10234

CAS No.: 379231-04-6

Purity: 99.92%

Synonyms: AZD0530

Target:

Src Autophagy

Research Areas:

Cancer

Saracatinib (AZD0530) is a potent Src family inhibitor with IC₅₀s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases .

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48

Saracatinib difumarate

48 Publications Verification

Cat. No.: HY-10234A

CAS No.: 893428-72-3

Purity: 99.24%

Synonyms: AZD0530 difumarate

Target:

Src

Research Areas:

Cancer

Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .

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40

R406

40 Cited Publications

Cat. No.: HY-12067

CAS No.: 841290-81-1

Purity: 96.70%

Target:

Syk FLT3 Apoptosis

Research Areas:

Inflammation/Immunology Cancer

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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40

R406 free base

40 Cited Publications

Cat. No.: HY-11108

CAS No.: 841290-80-0

Purity: 99.80%

Target:

Syk FLT3 Apoptosis

Research Areas:

Inflammation/Immunology Cancer

R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 free base reduces immune complex-mediated inflammation . R406 free base also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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24

SU6656

24 Cited Publications

Cat. No.: HY-B0789

CAS No.: 330161-87-0

Target:

Src FAK Akt

Research Areas:

Cancer

SU6656 is a Src family kinases inhibitor with IC₅₀s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

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20

Fostamatinib

20 Cited Publications

Cat. No.: HY-13038A

CAS No.: 901119-35-5

Purity: 99.70%

Synonyms: R788

Target:

Syk FLT3

Research Areas:

Inflammation/Immunology Cancer

Fostamatinib (R788) is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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20

Fostamatinib Disodium

20 Cited Publications

Cat. No.: HY-13038

CAS No.: 1025687-58-4

Purity: 99.88%

Synonyms: R788Disodium

Target:

Syk FLT3

Research Areas:

Inflammation/Immunology Cancer

Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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20

Fostamatinib disodium hexahydrate

20 Cited Publications

Cat. No.: HY-13038B

CAS No.: 914295-16-2

Purity: 99.51%

Synonyms: R788 disodium hexahydrate

Target:

Syk FLT3

Research Areas:

Inflammation/Immunology Cancer

Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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14

Bafetinib

14 Cited Publications

Cat. No.: HY-50868

CAS No.: 859212-16-1

Synonyms: INNO-406; NS-187

Target:

Bcr-Abl Src Apoptosis

Research Areas:

Cancer

Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity .

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12

A 419259

12 Cited Publications

Cat. No.: HY-15764

CAS No.: 364042-47-7

Purity: 99.75%

Synonyms: RK-20449

Target:

Src Apoptosis

Research Areas:

Cancer

A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, has high selectivity towards the Src family. A 419259 shows inhibitory effect for Src, Lck and Lyn with IC₅₀ of 9 nM, <3 nM and <3 nM, respectively .

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12

A 419259 trihydrochloride

12 Cited Publications

Cat. No.: HY-15764A

CAS No.: 1435934-25-0

Purity: 99.21%

Synonyms: RK 20449 trihydrochloride

Target:

Src Apoptosis

Research Areas:

Cancer

A 419259 trihydrochloride is a Src family kinases inhibitor with IC₅₀s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively .

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8

TL02-59

8 Cited Publications

Cat. No.: HY-112852

CAS No.: 1315330-17-6

Purity: 98.47%

Target:

Src Apoptosis

Research Areas:

Cancer

TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC₅₀ of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC₅₀s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth .

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7

LYN-1604

7 Cited Publications

Cat. No.: HY-101923

CAS No.: 2088939-99-3

Purity: 99.41%

Target:

ULK Autophagy Apoptosis

Research Areas:

Cancer

LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC) .

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7

LYN-1604 dihydrochloride

7 Cited Publications

Cat. No.: HY-101923B

CAS No.: 2310109-38-5

Purity: 99.55%

Target:

ULK Autophagy Apoptosis

Research Areas:

Cancer

LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC) .

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6

Tolimidone

6 Cited Publications

Cat. No.: HY-59047

CAS No.: 41964-07-2

Synonyms: MLR-1023

Target:

Src

Research Areas:

Metabolic Disease

Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC₅₀ of 63 nM.

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5

Masitinib

5 Cited Publications

Cat. No.: HY-10209

CAS No.: 790299-79-5

Purity: 99.95%

Synonyms: AB1010

Target:

c-Kit PDGFR Src FGFR FAK Apoptosis

Research Areas:

Cancer

Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity .

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5

Masitinib mesylate

5 Cited Publications

Cat. No.: HY-10209A

CAS No.: 1048007-93-7

Purity: 99.51%

Synonyms: AB-1010 mesylate

Target:

c-Kit PDGFR Src FGFR Apoptosis

Research Areas:

Cancer

Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity .

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