28 Results for "

M1 phenotypes

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "M1 phenotypes" in MCE Product Catalog:

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2
KPLH1130
KPLH1130
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2 Cited Publications
Cat. No.: HY-128578
CAS No.: 906669-07-6
Purity:  99.86%
Target:  

PDHK NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase

Research Areas:  

Metabolic Disease Inflammation/Immunology

KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions .
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Icrucumab
Icrucumab
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1 Cited Publications
Cat. No.: HY-P99364
CAS No.: 1024603-92-6
Synonyms: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1

Target:  

VEGFR Apoptosis p38 MAPK Akt

Research Areas:  

Endocrinology Cancer

Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is an IgG1 antibody inhibitor targeting VEGFR-1/FLT1 with anti-tumor activity. By blocking ligand-dependent phosphorylation and downstream signal transduction, Icrucumab reduces the activities of MAPK and Akt in breast cancer xenograft models, inhibits the proliferation and invasion of VEGFR-1-positive tumor cells, and reverses the conversion of M1 macrophages to the pro-tumor M2-like phenotype. Icrucumab also inhibits tumor cell proliferation, promotes apoptosis, and effectively suppresses tumor growth through direct targeting of tumors and host support mechanisms. In addition, Icrucumab exhibits a synergistic effect when combined with chemotherapeutic agents, and it is used in research related to various cancers including advanced solid malignancies, thyroid cancer, melanoma, and lung cancer .
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Dihydronicotinamide riboside
Dihydronicotinamide riboside
0 Images
1 Cited Publications
Cat. No.: HY-W614507
CAS No.: 19132-12-8
Target:  

NADPH Oxidase Apoptosis Bcl-2 Family

Research Areas:  

Metabolic Disease Cancer

Dihydronicotinamide riboside is a potent NAD + concentration enhancer. Dihydronicotinamide riboside modulates targets BAX, PUMA, NQO2, and IκB kinase. Dihydronicotinamide riboside mediates apoptosis, induces pro-oxidant activity, mitochondrial dysfunction, metabolic dysregulation, redox modulation, and pro-inflammatory M1 phenotype induction. Dihydronicotinamide riboside increases intracellular and mitochondrial NAD + levels, maintains cell survival against NAD +-depleting genotoxins. Dihydronicotinamide riboside can be used for the research of hepatocellular carcinoma .
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CSF1R-IN-3
CSF1R-IN-3
0 Images
1 Cited Publications
Cat. No.: HY-139990
CAS No.: 2760584-90-3
Purity:  98.26%
Target:  

c-Fms

Research Areas:  

Cancer

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity .
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KS-133 TFA
KS-133 TFA
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Cat. No.: HY-P6292A
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC50 values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation .
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2,4,5-Trimethoxybenzoic acid
2,4,5-Trimethoxybenzoic acid
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Cat. No.: HY-Y0586
CAS No.: 490-64-2
Synonyms: Asaronic acid
Category:  

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