239 Results for "

MCL REC-1

" in MedChemExpress (MCE) Product Catalog:
Products (239)

239 Results for "MCL REC-1" in MCE Product Catalog:

513
MK-2206
MK-2206
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513 Publications Verification
Cat. No.: HY-108232
CAS No.: 1032349-77-1
Purity:  99.72%
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

MK-2206 is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia [1] .
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513
MK-2206 dihydrochloride
MK-2206 dihydrochloride
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513 Publications Verification
Cat. No.: HY-10358
CAS No.: 1032350-13-2
Purity:  99.94%
Synonyms: MK-2206 (2HCl)
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia [1] .
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119
S63845
S63845
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119 Cited Publications
Cat. No.: HY-100741
CAS No.: 1799633-27-4
Purity:  99.81%
Target:  

Bcl-2 Family

Research Areas:  

Cancer

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 [1].
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24
AZD-5991
AZD-5991
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24 Cited Publications
Cat. No.: HY-101533
CAS No.: 2143061-81-6
Purity:  99.79%
Target:  

Bcl-2 Family

Research Areas:  

Cancer

AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay [1].
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20
A-1210477
A-1210477
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20 Cited Publications
Cat. No.: HY-12468
CAS No.: 1668553-26-1
Purity:  99.86%
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Cancer

A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM [1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .
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19
MIK665
MIK665
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19 Cited Publications
Cat. No.: HY-112218
CAS No.: 1799631-75-6
Purity:  99.11%
Synonyms: S-64315
Target:  

Bcl-2 Family

Research Areas:  

Cancer

MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor [1]. MIK665 has an IC50 of 1.81 nM for MCL1 .
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13
BAY 61-3606 dihydrochloride
BAY 61-3606 dihydrochloride
0 Images
13 Cited Publications
Cat. No.: HY-14985
CAS No.: 648903-57-5
Purity:  99.91%
Target:  

Syk Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM [1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell . BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates . Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells .
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12
BT2
BT2
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12 Cited Publications
Cat. No.: HY-114855
CAS No.: 34576-94-8
Purity:  99.81%
Target:  

Bcl-2 Family

Research Areas:  

Metabolic Disease

BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) [1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM .
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12
SGI-1776 free base
SGI-1776 free base
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12 Cited Publications
Cat. No.: HY-13287
CAS No.: 1025065-69-3
Purity:  99.35%
Target:  

Pim Apoptosis FLT3 PPAR FASTK STAT Mitochondrial Metabolism DNA/RNA Synthesis Bcl-2 Family

SGI-1776 free base is an orally active Pim kinase and FLT3 inhibitor with IC50 values of 7 nM, 363 nM, 69 nM, and 44 nM for Pim-1, Pim-2, Pim-3, and FLT3, respectively. SGI-1776 free base downregulates C/EBP-α, PPAR-γ, FAS, Leptin, and RANTES, and decreases STAT-3 phosphorylation. SGI-1776 free base induces Apoptosis, cell cycle arrest, mitochondrial depolarization, and reduces RNA synthesis, protein synthesis, and Mcl-1. SGI-1776 free base inhibits adipogenesis and lipid accumulation. SGI-1776 free base has anticancer activity against leukemia [1] .
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11
Angelicin
Angelicin
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11 Cited Publications
Cat. No.: HY-N0763
CAS No.: 523-50-2
Synonyms: Isopsoralen
Category:  

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