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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
MIZ1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "MIZ1" in MCE Product Catalog:
Cat. No.: HY-P703490
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BTB domain-containing protein
Species:
Others
Source:
E. coli
Cat. No.: HY-W320366
CAS No.: 896074-75-2
Target:
Research Areas:
TopBP1-IN-5 is a TopBP1-BRCT7/8 inhibitor (IC50=2.47-3.8 nM). TopBP1-IN-5 selectively disrupts the interaction of TopBP1-BRCT7/8 with E2F1, mutp53, MIZ1, PLK1, CIP2A, and Top2A, without affecting BRCT1/2- and BRCT5-mediated interactions. TopBP1-IN-5 activates caspase-3/7 and caspase-8 to induce prometaphase arrest, mitotic catastrophe, and apoptosis, while inhibiting the MYC transcriptional program and enhancing the binding of MIZ1 to the p21Cip1 promoter. TopBP1-IN-5 exhibits broad-spectrum anticancer activity in triple-negative breast cancer, ovarian cancer, lung cancer, and acute myeloid leukemia models, and can be used for research on related cancers [1].
Cat. No.: HY-189209
CAS No.: 850824-74-7
Target:
Research Areas:
TopBP1-IN-3 is an inhibitor of the TopBP1 BRCT7/8 domain. TopBP1-IN-3 disrupts the BRCT7/8-dependent interactions between TopBP1 and E2F1, mutp53, MIZ1, PLK1, and CIP2A, without affecting its protein binding mediated by other BRCT domains. TopBP1-IN-3 can be used for the research of ovarian cancer and breast cancer [1].
Cat. No.: HY-P71437
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBTB17; Zinc Finger And BTB Domain Containing 17; ZNF151; ZNF60; Zinc Finger Protein 60; PHZ-67; MIZ1; Zinc Finger And BTB Domain-Containing Protein 17; Zinc Finger Protein 151 (PHZ-67); Myc-Interacting Zinc Finger Protein 1; Myc-Interacting Zn Finger Pro
Species:
Human
Source:
E. coli
Cat. No.: HY-RS15965
Target:
Research Areas:
ZBTB17 Human Pre-designed siRNA Set A contains three designed siRNAs for ZBTB17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21220
Target:
Research Areas:
Zbtb17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Zbtb17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10474
Target:
Research Areas:
PIAS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PIAS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22729
Target:
Research Areas:
Pias2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pias2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS29243
Target:
Research Areas:
Pias2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pias2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
