17 Results for "

MLKL phosphorylation

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "MLKL phosphorylation" in MCE Product Catalog:

1
PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1
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1 Cited Publications
Cat. No.: HY-156591
CAS No.: 3032600-90-8
Purity:  99.76%
Target:  

PROTACs Mixed Lineage Kinase Necroptosis

Research Areas:  

Others

PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death .
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MLKL-IN-6
MLKL-IN-6
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Cat. No.: HY-156119
CAS No.: 3080148-24-6
Purity:  98.57%
Target:  

Mixed Lineage Kinase Necroptosis

Research Areas:  

Metabolic Disease Cancer

MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects .
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RIPK3-IN-3
RIPK3-IN-3
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Cat. No.: HY-149393
CAS No.: 3052303-53-1
Purity:  95.98%
Target:  

Mixed Lineage Kinase RIP kinase

Research Areas:  

Cancer

RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion .
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RIP1-IN-1
RIP1-IN-1
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Cat. No.: HY-173185
Target:  

RIP kinase Necroptosis

Research Areas:  

Inflammation/Immunology

RIP1-IN-1 is an orally active RIP1 inhibitor with strong RIP1 binding affinity (Kd: 110 nM). RIP1-IN-1 exhibits strong anti-necroptosis activity. RIP1-IN-1 effectively inhibits the formation of necrosomes by blocking the phosphorylation of RIP1, RIP3 and MLKL signaling pathways. RIP1-IN-1 inhibits necroptosis and can be used in the study of acute liver injury .
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MLKL-IN-3
MLKL-IN-3
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Cat. No.: HY-151541
CAS No.: 3031406-27-3
Target:  

Mixed Lineage Kinase Necroptosis

Research Areas:  

Neurological Disease

MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM . MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MLKL-IN-4
MLKL-IN-4
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Cat. No.: HY-151542
CAS No.: 3031406-17-1
Target:  

Mixed Lineage Kinase Necroptosis RIP kinase

Research Areas:  

Neurological Disease

MLKL-IN-4 (compound 56) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-4 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 82 nM . MLKL-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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RIPK1-IN-17
RIPK1-IN-17
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Cat. No.: HY-157039
CAS No.: 3033385-59-7
Purity:  97.09%
Target:  

RIP kinase Necroptosis Mixed Lineage Kinase

Research Areas:  

Inflammation/Immunology

RIPK1-IN-17 is an orally active, selective RIPK1 inhibitor (Kd = 17 nM) and shows no significant inhibition to RIPK3. RIPK1-IN-17 specifically inhibits necroptosis rather than apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation. RIPK1-IN-17 protects mice from hypothermia and death. RIPK1-IN-17 can be used for the study of necroptosis-related diseases such as inflammatory response syndrome (SIRS) .
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RIPK1-IN-34
RIPK1-IN-34
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Cat. No.: HY-178464
CAS No.: 3065634-19-4
Target:  

RIP kinase Mixed Lineage Kinase Necroptosis

Research Areas:  

Neurological Disease Inflammation/Immunology

RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 ＞ 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS) .
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ZYH-23
ZYH-23
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Cat. No.: HY-176407
Target:  

Necroptosis

Research Areas:  

Inflammation/Immunology Cancer

ZYH-23 is a potent necroptosis inhibitor. ZYH-23 blocks necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation via HSP90 targeting .
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WJH-C19
WJH-C19
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Cat. No.: HY-181596
Target:  

RIP kinase Mixed Lineage Kinase Apoptosis

Research Areas:  

Inflammation/Immunology

WJH-C19 is an orally active RIPK1 inhibitor with an IC50 of 5.7 nM. WJH-C19 inhibits the RIPK1/RIPK3/MLKL signaling axis, blocks RIPK1 phosphorylation, suppresses the phosphorylation of downstream RIPK3 and MLKL, disrupts necrosome formation, and exhibits protective effects against necroptosis (Apoptosis) in multiple cell lines. WJH-C19 ameliorates symptoms of inflammatory bowel disease in a mouse colitis model by regulating the necroptosis pathway. WJH-C19 alleviates inflammation and bone destruction in a mouse model of rheumatoid arthritis. WJH-C19 is applicable to research related to inflammatory bowel disease and rheumatoid arthritis .
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RIPK3-IN-8
RIPK3-IN-8
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Cat. No.: HY-189220
Target:  

RIP kinase Necroptosis Interleukin Related

Research Areas:  

Inflammation/Immunology

RIPK3-IN-8 is an orally active and selective RIPK3 inhibitor with a Kd of 150 nM. RIPK3-IN-8 disrupts the formation of the RIPK3-MLKL necrosome and reduces the phosphorylation of downstream MLKL. RIPK3-IN-8 inhibits necroptosis. RIPK3-IN-8 increases the survival rate in a mouse model of TNF-α/Z-VAD-fmk (HY-16658B)-induced systemic inflammatory response syndrome. RIPK3-IN-8 is used for the research of systemic inflammatory response syndrome .
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RIPK1-IN-42
RIPK1-IN-42
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Cat. No.: HY-184686
Target:  

RIP kinase Mixed Lineage Kinase Necroptosis

Research Areas:  

Inflammation/Immunology

RIPK1-IN-42 is an orally active RIPK1 inhibitor with a Kd of 21 nM. RIPK1-IN-42 inhibits the phosphorylation of RIPK1, suppresses the phosphorylation of downstream RIPK3 and MLKL, blocks necrosome formation, and inhibits necroptosis. RIPK1-IN-42 alleviates hypothermia, suppresses the elevation of pro-inflammatory cytokine levels, and reduces organ damage. RIPK1-IN-42 can be used for the research of systemic inflammatory response syndrome .
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RIPK1-IN-39
RIPK1-IN-39
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Cat. No.: HY-180806
CAS No.: 3065634-42-3
Target:  

RIP kinase Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease

RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research .
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RIPK1-IN-38
RIPK1-IN-38
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Cat. No.: HY-179680
CAS No.: 3092834-30-2
Target:  

RIP kinase Necroptosis Mixed Lineage Kinase Lactate Dehydrogenase Interleukin Related

Research Areas:  

Inflammation/Immunology

RIPK1-IN-38 is an orally active RIPK1 inhibitor with an IC50 value of 27 nM. RIPK1-IN-38 can inhibit the phosphorylation of RIPK1 and its downstream signaling molecules RIPK3 and MLKL. RIPK1-IN-38 exhibits anti-necroptotic activity. RIPK1-IN-38 has excellent anti-inflammatory efficacy in both the SIRS model and GVHD model. RIPK1-IN-38 can be used for the research of inflammatory and immune-related diseases .
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RIPK1-IN-41
RIPK1-IN-41
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Cat. No.: HY-183781
Target:  

RIP kinase Necroptosis

Research Areas:  

Inflammation/Immunology

RIPK1-IN-41 is an orally active RIPK1 inhibitor with an IC50 of 92 nM and a KD of 106.8 nM. RIPK1-IN-41 reduces the phosphorylation level of RIPK1, inhibits necrosome formation, blocks the activation of RIPK3 and MLKL, maintains mitochondrial and lysosomal functions, preserves cell membrane integrity, and suppresses necroptosis. RIPK1-IN-41 alleviates hypothermia and multi-organ damage in a mouse model of systemic inflammatory response syndrome induced by mTNF-α. RIPK1-IN-41 is applicable to research related to systemic inflammatory response syndrome .
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RIPK1/RIPK3-PPI-IN-1
RIPK1/RIPK3-PPI-IN-1
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Cat. No.: HY-183564
CAS No.: 2915280-95-2
Target:  

RIP kinase Necroptosis Interleukin Related

Research Areas:  

Inflammation/Immunology

RIPK1/RIPK3-PPI-IN-1 is an orally active dual-target inhibitor of RIPK1/RIPK3, with a Kd value of 2.4 nM for RIPK1 and 24 nM for RIPK3. RIPK1/RIPK3-PPI-IN-1 inhibits the phosphorylation of RIPK1, RIPK3 and MLKL, thereby suppressing necroptosis. RIPK1/RIPK3-PPI-IN-1 restores body temperature, improves survival rate, and reduces IL-1β/IL-6 levels in serum and multiple organs of Mus musculus, thus alleviating TNF-α-induced systemic inflammatory response syndrome. RIPK1/RIPK3-PPI-IN-1 can be used in research related to systemic inflammatory response syndrome .
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Chiisanogenin
Chiisanogenin
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Cat. No.: HY-N20708
CAS No.: 89353-99-1
Category:  

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