10654 Results for "

MM231 cells

" in MedChemExpress (MCE) Product Catalog:

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4270

Cell Counting Kit-8

4270 Publications Verification

Cat. No.: HY-K0301

Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.The 5 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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1851

Ferrostatin-1

1851 Cited Publications

Cat. No.: HY-100579

CAS No.: 347174-05-4

Purity: 99.71%

Synonyms: Fer-1

Target:

Ferroptosis Fungal

Research Areas:

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

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899

Cisplatin

899 Cited Publications

Cat. No.: HY-17394

CAS No.: 15663-27-1

Synonyms: cis-Platinum; CDDP; cis-Diaminodichloroplatinum

Target:

DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase

Research Areas:

Cancer

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

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891

H2DCFDA

891 Cited Publications

Cat. No.: HY-D0940

CAS No.: 4091-99-0

Synonyms: DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate

Target:

Fluorescent Dye Reactive Oxygen Species (ROS)

Research Areas:

Others

H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=492/517 nm) .

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669

ML385

669 Cited Publications

Cat. No.: HY-100523

CAS No.: 846557-71-9

Purity: 99.96%

Target:

Keap1-Nrf2 Ferroptosis Apoptosis mTOR

Research Areas:

Cardiovascular Disease Cancer

ML385 is a potent and selective Nrf2 inhibitor with an IC₅₀ of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .

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629

Y-27632

629 Cited Publications

Cat. No.: HY-10071

CAS No.: 146986-50-7

Purity: 99.46%

Target:

ROCK NADPH Oxidase mTOR Reactive Oxygen Species (ROS) NF-κB Apoptosis Akt Autophagy PAK Ras

Research Areas:

Cancer

Y-27632 is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .

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629

Y-27632 hydrochloride hydrate

629 Cited Publications

Cat. No.: HY-10071A

CAS No.: 331752-47-7

Target:

ROCK NF-κB Apoptosis Autophagy Akt mTOR NADPH Oxidase Reactive Oxygen Species (ROS) PAK Ras

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Y-27632 hydrochloride hydrate is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .

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601

RSL3

601 Cited Publications

Cat. No.: HY-100218A

CAS No.: 1219810-16-8

Purity: 99.90%

Synonyms: (1S,3R)-RSL3

Target:

p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

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