65 Results for "

MT cell

" in MedChemExpress (MCE) Product Catalog:
Products (65)

65 Results for "MT cell" in MCE Product Catalog:

9
Mavorixafor
Mavorixafor
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9 Publications Verification
Cat. No.: HY-50101
CAS No.: 558447-26-0
Synonyms: AMD-070; AMD-11070
Target:  

CXCR HIV

Research Areas:  

Infection Endocrinology Cancer

Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor can be used for the study of WHIM syndrome .
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9
Mavorixafor trihydrochloride
Mavorixafor trihydrochloride
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9 Publications Verification
Cat. No.: HY-50101A
CAS No.: 2309699-17-8
Synonyms: AMD-070 trihydrochloride; AMD-11070 trihydrochloride
Target:  

CXCR HIV

Research Areas:  

Infection Endocrinology Cancer

Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.Mavorixafor trihydrochloride can be used for the study of WHIM syndrome .
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9
Mavorixafor hydrochloride
Mavorixafor hydrochloride
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9 Publications Verification
Cat. No.: HY-50101C
CAS No.: 880549-30-4
Synonyms: AMD-070 hydrochloride; AMD-11070 hydrochloride
Target:  

CXCR HIV

Research Areas:  

Infection Cancer

Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome .
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5
I3MT-3
I3MT-3
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5 Cited Publications
Cat. No.: HY-128206
CAS No.: 459420-09-8
Purity:  99.98%
Synonyms: HMPSNE
Target:  

Hippo (MST)

Research Areas:  

Metabolic Disease

I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST .
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2
N6-Methyladenosine (Standard)
N6-Methyladenosine (Standard)
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2 Cited Publications
Cat. No.: HY-N0086R
CAS No.: 1867-73-8
Synonyms: 6-Methyladenosine (Standard); N-Methyladenosine (Standard)
Category:  

Natural Products Microorganisms Endogenous metabolite

Target:  

Endogenous Metabolite Influenza Virus Reference Standards

N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .
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1
Tetrachloroauric acid
Tetrachloroauric acid
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1 Cited Publications
Cat. No.: HY-W035091
CAS No.: 16903-35-8
Target:  

Biochemical Assay Reagents

Research Areas:  

Cardiovascular Disease Neurological Disease

Tetrachloroauric acid is an Au (III) compound and bilayer disruptor that can be used to damage red blood cells. Tetrachloroauric acid specifically disrupts the bilayer structure of representative phospholipids (dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine) in human red blood cell membranes, and induces morphological changes in intact human red blood cells. Tetrachloroauric acid causes downregulation of MT I-II and GFAP expression in the mouse brain following chronic treatment. Tetrachloroauric acid is being used in studies related to neurotoxicity and hematotoxicity, including analyses of human red blood cells and molecular models of red blood cell membranes, as well as immunohistochemical evaluation of the mouse brain .
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1
S-22153
S-22153
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1 Cited Publications
Cat. No.: HY-114962
CAS No.: 180304-07-8
Purity:  99.88%
Target:  

Melatonin Receptor

Research Areas:  

Neurological Disease

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes .
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1
SARS-CoV-IN-3
SARS-CoV-IN-3
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1 Cited Publications
Cat. No.: HY-135858
CAS No.: 888958-27-8
Purity:  99.36%
Target:  

SARS-CoV Parasite HIV

Research Areas:  

Infection

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells .
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1
SARS-CoV-IN-2
SARS-CoV-IN-2
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1 Cited Publications
Cat. No.: HY-135856
CAS No.: 888958-26-7
Purity:  98.66%
Target:  

SARS-CoV Parasite HIV

Research Areas:  

Infection

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .
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MT-125
MT-125
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Cat. No.: HY-174406
Target:  

Myosin PDGFR Reactive Oxygen Species (ROS) Ferroptosis Akt mTOR ERK

Research Areas:  

Cancer

MT-125 is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki,NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM). MT-125 can pass through the blood-brain barrier. MT-125 induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 can enhance the PDGFR signaling pathway. MT-125 can be used for research on glioblastoma.
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Amiselimod hydrochloride
Amiselimod hydrochloride
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Cat. No.: HY-16734A
CAS No.: 942398-84-7
Synonyms: MT-1303 hydrochloride
Target:  

LPL Receptor

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases .
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DpC
DpC
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Cat. No.: HY-114243
CAS No.: 1382469-39-7
Purity:  98.28%
Target:  

NF-κB JNK Caspase Apoptosis Interleukin Related

Research Areas:  

Neurological Disease Cancer

DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
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MT-125 free base
MT-125 free base
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Cat. No.: HY-174406A
CAS No.: 2404652-80-6
Target:  

Myosin PDGFR Reactive Oxygen Species (ROS) Ferroptosis Akt mTOR ERK

Research Areas:  

Inflammation/Immunology Cancer

MT-125 free base is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki,NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM). MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma.
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Loviride
Loviride
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Cat. No.: HY-15355
CAS No.: 147362-57-0
Purity:  99.59%
Synonyms: R 89439
Target:  

Reverse Transcriptase HIV

Research Areas:  

Infection

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells .
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MT 63-78
MT 63-78
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Cat. No.: HY-W058849
CAS No.: 1179347-65-9
Target:  

AMPK mTOR Apoptosis

Research Areas:  

Cancer

MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects .
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MT-4
MT-4
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Cat. No.: HY-128595
CAS No.: 2327925-35-7
Purity:  99.84%
Target:  

Transglutaminase

Research Areas:  

Cancer

MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.
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TAT (47-57) GGG-Cys(Npys)
TAT (47-57) GGG-Cys(Npys)
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Cat. No.: HY-P4123
CAS No.: 1231898-26-2
Target:  

MMP

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

TAT (47-57) GGG-Cys (Npys) is a cell-penetrating peptide and delivery carrier derived from TAT. TAT (47-57) GGG-Cys (Npys) facilitates the translocation of conjugated drug molecules across cell membranes. TAT (47-57) GGG-Cys (Npys) acts as a delivery carrier for MT1-MMP inhibitors. TAT (47-57) GGG-Cys (Npys) is applicable to research on diseases associated with MT1-MMP activity, such as cancer, arthritis, heart disease, and vascular disorders .
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AA-BR-157
AA-BR-157
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Cat. No.: HY-168969
Target:  

PROTACs

Research Areas:  

Neurological Disease Cancer

AA-BR-157 is a metallothionein 2A (MT2A) PROTAC degrader, DC50 is 200 nM (MT2A overexpressed in MDA-MB-231 cells). AA-BR-157 increases intracellular zinc levels, downregulates DIAPH3, disrupts cytoskeleton remodeling, and reduces the migration and invasion abilities of cancer cells. AA-BR-157 can be used for research on triple-negative breast cancer and glioblastoma .
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Ethyl salvianolate A
Ethyl salvianolate A
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Cat. No.: HY-N16050
CAS No.: 1015171-68-2
Synonyms: Ethyl salvionolate A
Category:  

Simple Phenylpropanols Phenylpropanoids Plants 500 - Internal Server Error | MedChemExpress

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