9

Mavorixafor

9 Publications Verification

Cat. No.: HY-50101

CAS No.: 558447-26-0

Synonyms: AMD-070; AMD-11070

Target:

CXCR HIV

Research Areas:

Infection Endocrinology Cancer

Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC₅₀ value of 13 nM against CXCR4 ¹²⁵I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC₅₀ of 1 and 9 nM, respectively. Mavorixafor can be used for the study of WHIM syndrome .

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9

Mavorixafor trihydrochloride

9 Publications Verification

Cat. No.: HY-50101A

CAS No.: 2309699-17-8

Synonyms: AMD-070 trihydrochloride; AMD-11070 trihydrochloride

Target:

CXCR HIV

Research Areas:

Infection Endocrinology Cancer

Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC₅₀ value of 13 nM against CXCR4 ¹²⁵I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC₅₀ of 1 and 9 nM, respectively.Mavorixafor trihydrochloride can be used for the study of WHIM syndrome .

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9

Mavorixafor hydrochloride

9 Publications Verification

Cat. No.: HY-50101C

CAS No.: 880549-30-4

Synonyms: AMD-070 hydrochloride; AMD-11070 hydrochloride

Target:

CXCR HIV

Research Areas:

Infection Cancer

Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC₅₀ value of 13 nM against CXCR4 ¹²⁵I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC₅₀ of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome .

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1

SARS-CoV-IN-3

1 Cited Publications

Cat. No.: HY-135858

CAS No.: 888958-27-8

Purity: 99.36%

Target:

SARS-CoV Parasite HIV

Research Areas:

Infection

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells .

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1

SARS-CoV-IN-2

1 Cited Publications

Cat. No.: HY-135856

CAS No.: 888958-26-7

Purity: 98.66%

Target:

SARS-CoV Parasite HIV

Research Areas:

Infection

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

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Loviride

Cat. No.: HY-15355

CAS No.: 147362-57-0

Purity: 99.59%

Synonyms: R 89439

Target:

Reverse Transcriptase HIV

Research Areas:

Infection

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC₅₀ of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells .

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MT-4

Cat. No.: HY-128595

CAS No.: 2327925-35-7

Purity: 99.84%

Target:

Transglutaminase

Research Areas:

Cancer

MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.

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