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120 Results for "

MYD88

" in MedChemExpress (MCE) Product Catalog:

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550

Resatorvid

550 Publications Verification

Cat. No.: HY-11109

CAS No.: 243984-11-4

Purity: 98.92%

Synonyms: TAK-242; CLI-095

Target:

Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .

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ST 2825

76 Cited Publications

Cat. No.: HY-50937

CAS No.: 894787-30-5

Target:

MyD88

Research Areas:

Inflammation/Immunology

ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity .

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TJ-M2010-5

35 Cited Publications

Cat. No.: HY-139397

CAS No.: 1357471-57-8

Purity: 99.85%

Target:

MyD88

Research Areas:

Cardiovascular Disease

TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway . TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .

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T6167923

16 Cited Publications

Cat. No.: HY-19744

CAS No.: 2437475-16-4

Target:

MyD88

Research Areas:

Inflammation/Immunology

T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC₅₀s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .

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