8

MALT1 inhibitor MI-2

8 Publications Verification

Cat. No.: HY-12276

CAS No.: 1047953-91-2

Purity: 99.73%

Target:

MALT1

Research Areas:

Cancer

MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC₅₀=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals .

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5

MLT-748

5 Cited Publications

Cat. No.: HY-115466

CAS No.: 1832578-30-9

Purity: 99.89%

Target:

MALT1

Research Areas:

Inflammation/Immunology

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC₅₀ of 5 nM .

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2

Safimaltib

2 Cited Publications

Cat. No.: HY-139399

CAS No.: 2230273-76-2

Purity: 99.63%

Synonyms: JNJ-67856633

Target:

MALT1

Research Areas:

Cancer

Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis .

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2

Mepazine

2 Cited Publications

Cat. No.: HY-121282

CAS No.: 60-89-9

Purity: 99.91%

Synonyms: Pecazine

Target:

MALT1 Apoptosis

Research Areas:

Cancer

Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC₅₀s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis .

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2

MLT-985

2 Cited Publications

Cat. No.: HY-142648

CAS No.: 1832576-25-6

Purity: 99.49%

Target:

MALT1

Research Areas:

Cancer

MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC₅₀ value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies .

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2

Mepazine hydrochloride

2 Cited Publications

Cat. No.: HY-121282A

CAS No.: 2975-36-2

Purity: 99.94%

Synonyms: Pecazine hydrochloride

Target:

MALT1 Apoptosis

Research Areas:

Cancer

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC₅₀s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis .

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1

Z-VRPR-FMK

1 Cited Publications

Cat. No.: HY-120231

CAS No.: 1381885-28-4

Target:

MALT1 NF-κB MMP

Research Areas:

Cancer

Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

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Zilemaltib

Cat. No.: HY-160698

CAS No.: 2661481-41-8

Synonyms: SGR-1505

Target:

MALT1 Apoptosis

Research Areas:

Cancer

SGR-1505 is an oral small molecule MALT1 inhibitor with anti-proliferative and antitumor activity.SGR-1505 inhibits MALT1 enzymatic activity to modulate NF-κB pathway gene expression.SGR-1505 induces modulation of cell cycle, DNA damage, and apoptosis-related genes in in vivo tumor samples.SGR-1505 exerts tumorostatic and regressive activity in ABC-DLBCL xenograft models.SGR-1505 can be used for the research of activated B cell-like diffuse large B cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms .

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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA

Cat. No.: HY-P1407

Target:

MALT1 NF-κB MMP

Research Areas:

Cancer

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

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INNO-220

Cat. No.: HY-174371

CAS No.: 3032576-92-1

Target:

Molecular Glues Casein Kinase MDM-2/p53 MALT1

Research Areas:

Neurological Disease Cancer

INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research.

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MLT-943

Cat. No.: HY-134820

CAS No.: 1832576-04-1

Purity: 99.77%

Target:

MALT1

Research Areas:

Inflammation/Immunology

MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar IC₅₀ across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 has anti-inflammatory activities and can be used for FcgR-mediated inflammation research .

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