399

Dimethyl sulfoxide, meets analytical specification of Ch.P.

399 Publications Verification

Synonyms: DMSO, meets analytical specification of Ch.P.

Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.

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66

Dimethyl sulfoxide

66 Cited Publications

Cat. No.: HY-Y0320C

CAS No.: 67-68-5

Synonyms: DMSO

Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity .
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.

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61

GSK484

61 Cited Publications

Cat. No.: HY-123606

CAS No.: 1652629-23-6

Target:

Protein Arginine Deiminase MHC

Research Areas:

Cardiovascular Disease Inflammation/Immunology

GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 ⁺ T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .

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11

Cromolyn disodium

11 Cited Publications

Cat. No.: HY-B0320A

CAS No.: 15826-37-6

Synonyms: Cromoglycate disodium; Cromoglicic acid disodium; FPL-670

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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11

Cromolyn

11 Cited Publications

Cat. No.: HY-B1619

CAS No.: 16110-51-3

Synonyms: Cromoglycate; Cromoglicic acid; FPL-670 free acid

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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9

PMX-53

9 Cited Publications

Cat. No.: HY-106178

CAS No.: 219639-75-5

Purity: 99.98%

Synonyms: 3D53

Target:

Complement System

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

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8

Compound 48/80

8 Cited Publications

Cat. No.: HY-115768

CAS No.: 94724-12-6

Purity: 99.98%

Synonyms: Poly-p-methoxyphenethylmethylamine

Target:

Phospholipase

Research Areas:

Neurological Disease Cancer

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .

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8

Compound 48/80 trihydrochloride

8 Cited Publications

Cat. No.: HY-130592

CAS No.: 848035-21-2

Purity: 99.95%

Synonyms: C48/80 trihydrochloride

Target:

Phospholipase

Research Areas:

Neurological Disease

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

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