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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Michael acceptor
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Michael acceptor" in MCE Product Catalog:
8
8 Cited Publications
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .
Cat. No.: HY-N2240
CAS No.: 108657-10-9
Category:
Plant Terpenoids Sesquiterpenes Compositae/Asteraceae Extract Eupatorium lindleyanum DC. Extract Disease Research Fields Cancer
Target:
Cat. No.: HY-W104821
CAS No.: 603-45-2
Target:
Keap1-Nrf2 Quinone Reductase PERK ATF6 Reactive Oxygen Species (ROS) Apoptosis SOD Glutathione Peroxidase
Research Areas:
Rosolic acid is a Michael acceptor molecule isolated from the rhizomes of Plantago asiatica L. Rosolic acid inhibits Keap1, promotes Nrf2 nuclear translocation, and upregulates HO-1 and NQO-1. Rosolic acid reduces ER stress markers PERK, ATF-6, GRP78, and CHOP, as well as oxidative stress, ROS production, inflammation, and apoptosis. Rosolic acid upregulates SOD, CAT, and GPx activities, induces angiogenesis and insulin secretion, and restores endothelial function and pancreatic beta cell protection under ER stress. Rosolic acid can be used in research on diabetes and endothelial dysfunction .
Cat. No.: HY-P10828
CAS No.: 1260620-30-1
Target:
Research Areas:
Cat. No.: HY-W800833
CAS No.: 55946-27-5
Target:
Research Areas:
Benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.
Cat. No.: HY-189745
HBP-10 is an anticancer agent containing a Michael acceptor. HBP-10 induces intracellular ROS accumulation, triggering IRE1α-JNK/CHOP-mediated ER stress, γ-H2AX-positive DNA damage, and caspase-dependent apoptosis (apoptosis). HBP-10's above effects are attenuated by NAC (HY-B0215). HBP-10 exerts antiproliferative and cytotoxic effects on NSCLC cells and shows certain selectivity for NSCLC cells. HBP-10 can be used for research on EGFR-mutant non-small cell lung cancer .
Cat. No.: HY-W392912A
CAS No.: 2833-24-1
Synonyms: Methyl (2E)-4-oxopent-2-enoate
Research Areas:
Methyl trans-4-oxo-2-pentenoate (Methyl (2E)-4-oxopent-2-enoate) is a heterofunctionalized dienophile containing both ketone and ester functional groups. The enone structure within the Methyl trans-4-oxo-2-pentenoate molecule makes it a highly reactive Michael acceptor capable of regioselective conjugate addition, which is commonly used in reactions for constructing complex ring systems such as the Robinson annulation. Methyl trans-4-oxo-2-pentenoate can serve as a substrate in the synthesis of α-(alkylmethylene) butyrolactone derivatives. Methyl trans-4-oxo-2-pentenoate participates in asymmetric Diels-Alder reactions promoted by chiral palladium complexes .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
