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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
65 Results for "
Mn2+
" in MedChemExpress (MCE) Product Catalog:
Products (65)
65 Results for "Mn2+" in MCE Product Catalog:
30
30 Publications Verification
Cat. No.: HY-W250119
CAS No.: 23411-34-9
Synonyms: EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate
4
4 Cited Publications
Cat. No.: HY-D0155
CAS No.: 288574-78-7
1
1 Cited Publications
Cat. No.: HY-P75979
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPM1A; Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform; Protein Phosphatase, Mg2+/Mn2+ Dependent 1A; Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A; Protein Phosphatase 1A; Protein Phosphatase 2C, Alpha Isoform; PP2Calpha; Alternati
Species:
Mouse
Source:
E. coli
Cat. No.: HY-NP164
Synonyms: Con A-HRP
Cat. No.: HY-E70110
CAS No.: 37288-54-3
Target:
Research Areas:
Endo-1,4-β-mannanase is an important catalyst that randomly cleaves the β-1,4-linkages in the main chain of mannan, releasing short-chain β-1,4-mannan and mannose. The catalytic activity of Endo-1,4-β-mannanase toward locust bean gum is enhanced by Mn 2+, Co 2+, Ca 2+, Ba 2+, Triton X-100, sodium azide and N-ethylmaleimide, completely inhibited by Hg 2+ and N-bromosuccinimide, and partially inhibited by EDTA and Cu 2+. Endo-1,4-β-mannanase can be used in studies related to plant hemicellulose degradation, biomass saccharification, elimination of anti-nutritional factors in feed, and manno-oligosaccharide prebiotics [2].
Cat. No.: HY-132188
CAS No.: 114995-15-2
Cat. No.: HY-E70373
CAS No.: 401941-75-1
Target:
Research Areas:
λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn 2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase
Target:
Research Areas:
Sphingomyelin phosphodiesterase, Streptomyces sp. is a sphingomyelin phosphodiesterase derived from the genus Streptomyces, which cleaves the phosphodiester bond of sphingomyelin. Sphingomyelin phosphodiesterase, Streptomyces sp. catalyzes the hydrolysis of sphingomyelin in micelles, synthetic substrates, erythrocyte ghost membranes and liposomes, as well as the hydrolysis of the substrate HNP. In the presence of Mg 2+ or Mn 2+ , Sphingomyelin phosphodiesterase, Streptomyces sp. induces hemolysis of bovine erythrocytes through the hydrolysis of membrane sphingomyelin [2].
Cat. No.: HY-164220
CAS No.: 2919466-30-9
Target:
Research Areas:
PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis .
Cat. No.: HY-173084
Target:
Research Areas:
BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC50 of 5 nM. BRD6257 activates p53 signaling pathway with an EC50 of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC50=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes .
Cat. No.: HY-P1188
CAS No.: 1207610-07-8
Target:
Research Areas:
Chondroitinase AC II is a glycosaminoglycan lyase (EC 4.2.2.5) discovered from Arthrobacter sp. CS01. Chondroitinase AC II exhibits broad substrate specificity toward CS-A, CS-C, and HA. Chondroitinase AC II cleaves the β-1,4-glycosidic bond between D-glucuronic acid and N-acetylgalactosamine through a β-elimination mechanism, producing unsaturated disaccharides and thereby degrading chondroitin sulfate and hyaluronic acid. Chondroitinase AC II activity is enhanced by Mn 2+ and inhibited by Zn 2+ and Hg 2+ . Chondroitinase AC II is used for CS oligosaccharide preparation and research related to nerve injury [2].
Target:
Research Areas:
Lipase, Aspergillus niger (Immobilized) is an immobilized triacylglycerol acyl hydrolase and biocatalyst. Lipase, Aspergillus niger (Immobilized) broadly catalyzes the hydrolysis of glycerol-long-chain fatty acid esters, exhibits positional selectivity for the 1,3-positions of glycerol, but shows low hydrolysis efficiency for castor oil. Lipase, Aspergillus niger (Immobilized) displays optimal activity at 45°C and pH 7.0, and remains stable at temperatures up to 60°C and over a broad pH range of 2.0-9.0. Lipase, Aspergillus niger (Immobilized) is activated by Ca 2+ and Mg 2+, but inhibited by Mn 2+, Fe 2+ and Zn 2+ [2] .
Cat. No.: HY-NP164B
Synonyms: Con A-AF488
Cat. No.: HY-W241345
CAS No.: 913542-71-9
Research Areas:
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
Cat. No.: HY-174849
Target:
Research Areas:
TdT-IN-1 (Compound 8c) is a selective and non-nucleoside terminal deoxynucleotidyl transferase (TdT) inhibitor with IC50 s of 0.11 and 0.19 μM for Mg 2+ and Mn 2+. TdT-IN-1 can be used for leukaemias and skin cancer research .
Cat. No.: HY-NP164D
Synonyms: Con A-AF405
Cat. No.: HY-NP164E
Synonyms: Con A-AF430
Cat. No.: HY-NP164I
Synonyms: Con A-AF546
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
