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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
N-Substituted
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "N-Substituted" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-B0847
CAS No.: 60207-90-1
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Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
Cat. No.: HY-Y1080
CAS No.: 19764-30-8
Synonyms: N-Acetyl-D-leucine
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Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .
Cat. No.: HY-130178
CAS No.: 1210501-46-4
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CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .
Synonyms: Mutagenic impurity of tenofovir disoproxil
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9-Propenyladenine (Mutagenic impurity of tenofovir disoproxil) is a purine derivative mutagenic impurity of Tenofovir Disoproxil (HY-13782A), and also serves as a capping group intermediate in the synthesis of N-substituted purines .
Cat. No.: HY-W009970
CAS No.: 6436-90-4
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Cat. No.: HY-B0847R
CAS No.: 60207-90-1
Research Areas:
Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
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Isopromethazine hydrochloride is an impurity in the pharmaceutical preparations of Promethazine (HY-B1296). Promethazine is an N-substituted phenothiazine with the actions and the uses of the antihistamines (H1-receptor antagonists) .
Cat. No.: HY-129661
CAS No.: 763023-14-9
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AH 7959 is an orally active N-substituted cyclohexyl methyl benzamide compound that has analgesic effects, the oral and subcutaneous ED50 of AH 7959 in mice is greater than 100 mg/kg .
Cat. No.: HY-120550
CAS No.: 111962-89-1
RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.
Cat. No.: HY-145275
CAS No.: 2758314-64-4
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EB-0176 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC50s of 0.6439 and 0.0011 μM, respectively. EB-0176 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0176 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses .
Cat. No.: HY-145274
CAS No.: 2832824-43-6
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EB-0156 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC50s of 0.0479 and less than 0.001 μM, respectively. EB-0156 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0156 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses .
Cat. No.: HY-100079R
CAS No.: 1446486-33-4
Synonyms: Mutagenic Impurity of Tenofovir Disoproxil (Standard); Tenofovir Impurity 2 (Standard)
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9-Propenyladenine (Standard) (Mutagenic Impurity of Tenofovir Disoproxil (Standard); Tenofovir Impurity 2 (Standard)) is the analytical standard of 9-Propenyladenine (HY-100079). This product is intended for research and analytical applications. 9-Propenyladenine (Mutagenic impurity of tenofovir disoproxil) is a purine derivative mutagenic impurity of Tenofovir Disoproxil (HY-13782A), and also serves as a capping group intermediate in the synthesis of N-substituted purines .
Cat. No.: HY-122351
CAS No.: 245650-17-3
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Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .
Cat. No.: HY-122351AR
CAS No.: 714229-20-6
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Advantame (Standard) is the analytical standard of Advantame. This product is intended for research and analytical applications. Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .
Cat. No.: HY-145273
CAS No.: 2832824-40-3
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EB-0150 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC50s of 0.73 and 0.0337 μM, respectively. EB-0150 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0150 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses . EB-0150 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W023557
CAS No.: 1072-87-3
Synonyms: 3-Methylmaleimide; 2-Methylmaleimide
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Citraconimide is a 3-methylmaleimide derivative. Citraconimide has thiol affinity and can undergo highly regioselective addition with a variety of alkyl thiols. Citraconimide derivatives show growth inhibitory activity against HeLa cells. Citraconimide can be modified by N-substitution, halogenation and other reactions for use in bioactive molecule design and drug development research .
Cat. No.: HY-W706595
CAS No.: 29805-52-5
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N,α-Diethylphenethylamine hydrochloride is an N-substituted amphetamine with an ethyl group attached to the amine. N,α-Diethylphenethylamine hydrochloride is an anorectic.
Cat. No.: HY-184371
CAS No.: 2907719-42-8
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MC-GGFG-Eribulin is a linker-payload of a tubulin inhibitor-based cytotoxic agent with an N-substituted maleimide group, conjugated via the MC-GGFG linker. MC-GGFG-Eribulin reacts with the thiol groups of reduced antibodies or antigen-binding fragments to form antibody-drug conjugates. MC-GGFG-Eribulin is applicable for cancer-related research .
Cat. No.: HY-208559
CAS No.: 169609-85-2
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Insecticidal agent 36 is an insecticidal N-(substituted arylmethyl)-4-[bis (substituted phenyl) methyl]piperidine, or its corresponding N-oxide or agriculturally acceptable salt. Insecticidal agent 36 exhibits insecticidal activity, with a growth inhibition rate of 95% at a concentration of 100 µM and a pI50 value of 5.1. Insecticidal agent 36 can be used in pest control research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
