Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
NFE2L2
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "NFE2L2" in MCE Product Catalog:
7
7 Publications Verification
Synonyms: CDDO ethyl amide; TP319; RTA 405
Target:
Research Areas:
CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
5
3
2
2 Cited Publications
Cat. No.: HY-P702844
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; Nuclear Factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP Transcription Factor 2; Nuclear Factor, Erythroid Derived 2, Like 2; NRF2; Nuclear Factor Erythroid-Derived 2-Like 2; Nuclear Factor Erythroid 2-Related Factor 2; Nuclear Factor, Erythroi
Species:
Mouse
Source:
E. coli
Cat. No.: HY-RS09245
Target:
Research Areas:
NFE2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for NFE2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09246
Target:
Research Areas:
Nfe2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfe2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09247
Target:
Research Areas:
Nfe2l2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nfe2l2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125995
CAS No.: 2230581-03-8
Target:
Research Areas:
NFE2L2 activator 3 (Compound 3) is a NFE2L2/NRF2 activator. NFE2L2 activator 3 specifically activates the NAD(P)H:quinone oxidoreductase (NQO1) enzyme, with its EC50 < 1 nM. NFE2L2 activator 3 can be used for research on respiratory system diseases such as chronic obstructive pulmonary disease .
Cat. No.: HY-145390A
Purity: 96.88%
Target:
Research Areas:
(R,R)-Nrf2 activator-1 is the enantiomer of Nrf2 activator-1. Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis .
Cat. No.: HY-177944
CAS No.: 2829198-49-2
Research Areas:
DC-PGKI is an orally active ATP-competitive PGK1 inhibitor(IC50 = 0.16 Μm, Kd = 99.08 nM). DC-PGKI stabilizes PGK1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. DC-PGKI-mediated inhibition of PGK1 leads to the accumulation of NRF2 (nuclear factor-erythroid factor 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and suppresses the LPS-induced expression of these genes. DC-PGKI can be used for the study of colitis .
Cat. No.: HY-P7S1785
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; Nuclear factor, erythroid derived 2, like 2; NFE2L2; NRF2
Species:
Human
Source:
E. coli
Cat. No.: HY-P704943
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; Nuclear Factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP Transcription Factor 2; Nuclear Factor, Erythroid Derived 2, Like 2; NRF2; Nuclear Factor Erythroid-Derived 2-Like 2; Nuclear Factor Erythroid 2-Related Factor 2; Nuclear Factor, Erythroi
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P72308A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; Nuclear Factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP Transcription Factor 2; Nuclear Factor, Erythroid Derived 2, Like 2; NRF2; Nuclear Factor Erythroid-Derived 2-Like 2; Nuclear Factor Erythroid 2-Related Factor 2; Nuclear Factor, Erythroid 2-Like 2; NRF-2; NFE2-Related Factor 2; Nuclear Factor, Erythroid 2 Like 2; IMDDHH; NF-E2-Related Factor 2; Nrf-2; Nuclear Factor Erythroid-Derived 2-Like 2 Transcript Variant 1
Species:
Human
Source:
E. coli
Cat. No.: HY-210438
Target:
Research Areas:
L013 is an orally active and selective NRF2 PROTAC degrader. L013 directly binds to the NRF2 protein and promotes NRF2 ubiquitination and UPS-related degradation through a Cullin-dependent, CRBN-related process. L013 inhibits RNA polymerase II transcriptional elongation and downregulates NFE2L2 transcript levels. L013 selectively reduces NRF2 protein/mRNA and inhibits proliferation/colony formation in esophageal squamous cell carcinoma cells with NRF2 hyperactivation. L013 inhibits tumor growth in the KYSE150 esophageal squamous cell carcinoma xenograft mouse model and reduces intratumoral NRF2 and Ki-67 protein levels. L013 can be used for research on esophageal squamous cell carcinoma and lung squamous cell carcinoma .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
