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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
NOD mice
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "NOD mice" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P5522A
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride
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Cat. No.: HY-P5523A
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Cat. No.: HY-P99148
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Cat. No.: HY-P5489
CAS No.: 849069-99-4
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Cat. No.: HY-P5396A
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Cat. No.: HY-P5523
CAS No.: 592520-07-5
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Cat. No.: HY-106055
CAS No.: 74817-61-1
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Murabutide is an immunomodulator and also a NOD2 receptor agonist . Murabutide enhances the signal transduction of ATR and NOD2, mediates the activation of the DDR pathway, and thereby repairs radiation-induced DNA double-strand breaks. Murabutide inhibits radiation-induced cell apoptosis and protects cells and mice from radiation-induced toxic damage. Murabutide induces the expression and DNA-binding activity of Oct-1 in macrophages, thereby inhibiting the transcription and replication of HIV-1. Murabutide reduces the expression levels of CD4 and CCR5 on the surface of macrophages, and induces the secretion of β-chemokines, TNF-α and IL-6. Murabutide enhances non-specific viral resistance and targets reticuloendothelial cells. Murabutide can be used in research related to radiation-induced damage and human immunodeficiency virus type 1 infection .
Cat. No.: HY-P5522
CAS No.: 877462-71-0
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid
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Cat. No.: HY-174437
CAS No.: 3047195-48-9
FLT3-IN-32 is a potent and orally active FLT3 inhibitor. FLT3-IN-32 shows high selectivity for FLT3 and efficiently inhibits FLT3-activating mutations and induces apoptosis. FLT3-IN-32 shows good tolerability in non-tumor bearing mice. FLT3-IN-32 demonstrates outstanding anti-tumor efficacy in MV4-11 bearing NOD/SCID mice, prolonging the survival noticeably. FLT3-IN-32 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P5396
CAS No.: 152468-44-5
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Cat. No.: HY-172617
CAS No.: 877810-03-2
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APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study .
Cat. No.: HY-178899
CAS No.: 1863978-06-6
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C14-Tri-LAN-Gly is a highly selective and potent NOD1 agonist. C14-Tri-LAN-Gly activates NOD1. C14-Tri-LAN-Gly inhibits the expression of cleaved-caspase3. C14-Tri-LAN-Gly upregulates A20 expression. C14-Tri-LAN-Gly protects mice from lethal hepatitis by inhibiting hepatocyte Apoptosis. C14-Tri-LAN-Gly inhibits osteoblastogenesis and promots osteoclastogenesis .
Cat. No.: HY-P5522AS
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid-13C3,15N dihydrochloride
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Isotope-Labeled Compounds NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV
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TriDAP- 13C3, 15N (L-Ala-γ-D-Glu-meso-diaminopimelic acid- 13C3, 15N) dihydrochloride is the 13C, 15N-labeled TriDAP dihydrochloride (HY-P5522A). TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP dihydrochloride enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP dihydrochloride downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP dihydrochloride decreases IκBα levels and increases p65 levels. TriDAP dihydrochloride induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP dihydrochloride increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP dihydrochloride can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection .
Cat. No.: HY-P992555
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Anti-Mouse BTLA/CD272 Antibody (6F7) is an anti-BTLA antibody that binds BTLA/CD272 and depletes BTLA + cells. Anti-Mouse BTLA/CD272 Antibody (6F7) increases IL-4, IL-10, IL-2, and IFN-γ expression, and decreases anti-PD-1-enhanced IL-12 (p40/p70). Anti-Mouse BTLA/CD272 Antibody (6F7) delays the onset of spontaneous diabetes in aged but not young female NOD mice, attenuates anti-PD-1-induced diabetes in both age groups, protects prediabetic NOD mice from anti-PD-1-induced insulitis, and reduces pancreatic islet B/helper T cell infiltration. Anti-Mouse BTLA/CD272 Antibody (6F7) can be used for research on type 1 diabetes and insulitis .
Cat. No.: HY-P5523AS
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iE-DAP- 13C5, 15N dihydrochloride is the 13C, 15N-labeled iE-DAP dihydrochloride (HY-P5523A). iE-DAP dihydrochloride is a Nod1 agonist. iE-DAP dihydrochloride activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of ZO-1 and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, MCP-1, IL-8 and MIP-1β in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth .
Cat. No.: HY-P992574
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Anti-Mouse CD226/DNAM-1 Antibody (480.1) is a rat IgG2a κ isotype blocking monoclonal antibody targeting CD226. Anti-Mouse CD226/DNAM-1 Antibody (480.1) competitively blocks the interaction between CD226 and its ligand CD155, inhibiting CD226-mediated costimulatory signaling. Anti-Mouse CD226/DNAM-1 Antibody (480.1) reduces CD4 + and CD8 + effector T cell proliferation and IFN‑γ secretion, and elevates STAT5 phosphorylation levels in regulatory T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) attenuates the severity of insulitis in NOD mice, reduces the risk of type 1 diabetes onset, and decreases infiltration of islet-specific IGRP-reactive CD8 + T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) can be used for research on CD226-mediated diseases, such as type 1 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
