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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
NPC disease
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "NPC disease" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
Cat. No.: HY-121315
CAS No.: 1550053-19-4
Target:
Research Areas:
BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases .
Cat. No.: HY-129980A
CAS No.: 136449-85-9
Research Areas:
NPC-15437 is a selective PKC inhibitor with an IC50 of 19 µM. NPC-15437 competitively inhibits phorbol ester- (Ki of 5 µM) and phosphatidylserine-induced (Ki of 12 µM) PKC activity. NPC-15437 does not inhibits cAMP-dependent or calcium/calmodulin-dependent protein kinases. NPC-15437 augments TRAIL-induced cell death in non-small cell lung cancer and medulloblastoma cells. NPC-15437 can be used for the research of non-small cell lung cancer, medulloblastoma, and neurological disease .
Cat. No.: HY-P74692
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NPC2; Epididymal Protein 1; NPC Intracellular Cholesterol Transporter 2; NP-C2; HE1; Epididymis Secretory Sperm Binding Protein; EDDM1; Tissue-Specific Secretory Protein; Niemann-Pick disease Type C2 Protein; Niemann-Pick disease, Type C2; Human Epididymi
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74693
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NPC2; Epididymal Protein 1; NPC Intracellular Cholesterol Transporter 2; NP-C2; HE1; Epididymis Secretory Sperm Binding Protein; EDDM1; Tissue-Specific Secretory Protein; Niemann-Pick disease Type C2 Protein; Niemann-Pick disease, Type C2; Human Epididymi
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74694
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: NPC2; Epididymal Protein 1; NPC Intracellular Cholesterol Transporter 2; NP-C2; HE1; Epididymis Secretory Sperm Binding Protein; EDDM1; Tissue-Specific Secretory Protein; Niemann-Pick disease Type C2 Protein; Niemann-Pick disease, Type C2; Human Epididymi
Species:
Human
Source:
HEK293
Cat. No.: HY-N15891
CAS No.: 1917340-40-9
Target:
Cat. No.: HY-182938
CAS No.: 1111050-17-9
Target:
Research Areas:
Autophagy activator-2 is a potent autophagy activator with EC50 values of 14.33 μM. Autophagy activator-2 acts as a proteostasis modulator and small-molecule chaperone that upregulates I1061T mutant NPC1 expression and facilitates cholesterol efflux. Autophagy activator-2 reduces lysosomal hydrolase levels. Autophagy activator-2 can be used for the study of Niemann-Pick Type C disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
