Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
93 Results for "
NTRK
" in MedChemExpress (MCE) Product Catalog:
Products (93)
93 Results for "NTRK" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: DS-6051b; AB-106; IBI-344
Target:
Research Areas:
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .
1
1 Cited Publications
Cat. No.: HY-P76116
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NTRK1; Tyrosine Kinase Receptor A; Neurotrophic Receptor Tyrosine Kinase 1; P140-TrkA; TRKA; Gp140trk; TRK; Trk-A; MTC; Neurotrophic Tyrosine Kinase Receptor Type 1; High Affinity Nerve Growth Factor Receptor; Tyrosine-Protein Kinase Receptor; Neurotrophi
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7308
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NTRK1; Tyrosine Kinase Receptor A; Neurotrophic Receptor Tyrosine Kinase 1; P140-TrkA; TRKA; Gp140trk; TRK; Trk-A; MTC; Neurotrophic Tyrosine Kinase Receptor Type 1; High Affinity Nerve Growth Factor Receptor; Tyrosine-Protein Kinase Receptor; Neurotrophic Tyrosine Kinase, Receptor, Type 1; Tyrosine Kinase Receptor; TRK1-Transforming Tyrosine Kinase Protein; Oncogene TRK; Tropomyosin Receptor Kinase A; TRK1; Tropomyosin-Related Kinase A
Species:
Human
Source:
HEK293
Cat. No.: HY-W070306
CAS No.: 1207836-10-9
Cat. No.: HY-RS09631
Target:
Research Areas:
NTRK2 Human Pre-designed siRNA Set A contains three designed siRNAs for NTRK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09634
Target:
Research Areas:
NTRK3 Human Pre-designed siRNA Set A contains three designed siRNAs for NTRK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-131003A
CAS No.: 1505514-27-1
Synonyms: DS-6051b free base; AB-106 free base; IBI-344 free base
Target:
Research Areas:
Taletrectinib (DS-6051b) free base is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .
Cat. No.: HY-E70870
Target:
Research Areas:
TRKB(NTRK2) is a member of tyrosine kinase gene family. TRKB is the primary receptor for brain-derived nerve growth factor (BDNF) and neurotrophin 4/5 (NT4/5). TRKB(NTRK2) Recombinant Human Active Protein Kinase is a recombinant TRKB(NTRK2) protein that can be used to study TRKB(NTRK2)-related functions .
Cat. No.: HY-E70869
Target:
Research Areas:
TRKA (also named NTRK1) is a potential new member of the tyrosine kinase gene family. TRKA is a receptor tyrosine kinase that is phosphorylated in response to NGF. A single transmembrane domain divides TRKA into an extracellular domain, important for NGF binding, and an intracellular tyrosine kinase domain, important for signal transduction. TRKA(NTRK1) Recombinant Human Active Protein Kinase is a recombinant TRKA(NTRK1) protein that can be used to study TRKA(NTRK1)-related functions .
Cat. No.: HY-W700297
CAS No.: 83647-33-0
Synonyms: KPI-285
K-106 (KPI-285) is a VEGFR antagonist that also inhibits neurotrophic tyrosine kinase receptors (NTRK). K-106 can be used for retinal research .
Cat. No.: HY-144321
CAS No.: 2758623-12-8
Target:
Research Areas:
Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers .
Cat. No.: HY-P991098
Target:
Research Areas:
Cat. No.: HY-RS09632
Target:
Research Areas:
Ntrk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntrk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09628
Target:
Research Areas:
NTRK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NTRK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09629
Target:
Research Areas:
Ntrk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09630
Target:
Research Areas:
Ntrk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09633
Target:
Research Areas:
Ntrk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntrk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09635
Target:
Research Areas:
Ntrk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntrk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09636
Target:
Research Areas:
Ntrk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntrk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-156086
CAS No.: 2937544-01-7
Target:
Research Areas:
TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKA G595R, TRKA G667C and TRKA F589L IC50s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC50 of 1.43-47.56 nM .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
