69 Results for "

NaV1.8

" in MedChemExpress (MCE) Product Catalog:
Products (69)

69 Results for "NaV1.8" in MCE Product Catalog:

10
Suzetrigine
Suzetrigine
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10 Publications Verification
Cat. No.: HY-148800
CAS No.: 2649467-58-1
Purity:  99.96%
Synonyms: VX-548
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy .
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4
ICA-121431
ICA-121431
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4 Cited Publications
Cat. No.: HY-16787
CAS No.: 313254-51-2
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease

ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).
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3
A-803467
A-803467
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3 Cited Publications
Cat. No.: HY-11079
CAS No.: 944261-79-4
Purity:  99.09%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter .
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2
Dexpramipexole dihydrochloride
Dexpramipexole dihydrochloride
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2 Cited Publications
Cat. No.: HY-17355A
CAS No.: 104632-27-1
Synonyms: (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride
Target:  

ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .
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2
Dexpramipexole
Dexpramipexole
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2 Cited Publications
Cat. No.: HY-17355B
CAS No.: 104632-28-2
Synonyms: (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704
Target:  

PINK1/Parkin Glutathione Peroxidase Sodium Channel ATP Synthase NOD-like Receptor (NLR) Mitophagy Ferroptosis Autophagy Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .
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1
PF-01247324
PF-01247324
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1 Cited Publications
Cat. No.: HY-101383
CAS No.: 875051-72-2
Purity:  99.63%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
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1
Bifenthrin
Bifenthrin
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1 Cited Publications
Cat. No.: HY-B0824
CAS No.: 82657-04-3
Target:  

Environmental Pollutants Sodium Channel

Research Areas:  

Neurological Disease

Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD50=0.15 ng/mg) and C. quinquefasciatus (LD50=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .
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VX-150
VX-150
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1 Cited Publications
Cat. No.: HY-139346
CAS No.: 1793080-72-4
Purity:  98.36%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research .
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Mambalgin 1 TFA
Mambalgin 1 TFA
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1 Cited Publications
Cat. No.: HY-P1441A
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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DSP-2230
DSP-2230
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Cat. No.: HY-125079
CAS No.: 1233231-30-5
Purity:  98.33%
Synonyms: ANP-230
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease Neurological Disease

DSP-2230 is the orally active inhibitor for voltage-gated sodium channel that inhibits Nav1.7-, Nav1.8-, and Nav1.9-derived sodium currents with IC50s of 7.1 μM, 11.4 μM and 6.7 μM, respectively. DSP-2230 can be used to improve neuropathic pain .
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Sodium Channel inhibitor 6
Sodium Channel inhibitor 6
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Cat. No.: HY-171244
CAS No.: 2877755-11-6
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Sodium Channel inhibitor 6 (compound I) is a selective Nav1.8 inhibitor that can be used in the study of neuropathic pain .
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Nav1.8-IN-2
Nav1.8-IN-2
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Cat. No.: HY-143481
CAS No.: 2756250-30-1
Target:  

Sodium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology

Nav1.8-IN-2 (compound 35A) is a Nav1.8 voltage-gated sodium ion inhibitor with an IC50 of 0.4 nM (HEK 293 cells). Nav1.8-IN-2 inhibits the activity of Nav1.8 voltage-gated sodium ion channels, mediates sodium ion influx in excitable cells, and is associated with the initiation and conduction of action potentials. Nav1.8-IN-2 can be used for research related to pain, cough, itching, etc .
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PF-06305591
PF-06305591
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Cat. No.: HY-114301
CAS No.: 1449473-97-5
Purity:  99.92%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile .
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PF 04531083
PF 04531083
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Cat. No.: HY-105283
CAS No.: 1079400-07-9
Purity:  98.96%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

PF 04531083 is an orally active and selective NaV1.8 blocker with an IC50 of 0.7 μM. PF 04531083 is a blood-brain barrier (BBB) penetrant compound. PF 04531083 can be used for the research of respiratory system and neuropathic/inflammatory pain .
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LTGO-33
LTGO-33
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Cat. No.: HY-157802
CAS No.: 2834106-06-6
Purity:  99.35%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research .
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Cyfluthrin
Cyfluthrin
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Cat. No.: HY-B1837
CAS No.: 68359-37-5
Target:  

Environmental Pollutants Sodium Channel

Research Areas:  

Infection

Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product .
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3'-Methoxydaidzein
3'-Methoxydaidzein
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Cat. No.: HY-N1847
CAS No.: 21913-98-4
Category:  

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