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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
429 Results for "
Nuclear receptor
" in MedChemExpress (MCE) Product Catalog:
Products (429)
429 Results for "Nuclear receptor" in MCE Product Catalog:
156
156 Publications Verification
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
126
126 Cited Publications
Target:
Research Areas:
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR).
CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM .
85
85 Cited Publications
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Category:
Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Cancer Alkaloid Dimers Apocynaceae Extract
Target:
85
85 Cited Publications
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Category:
Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Anti-aging Disease Research Fields Cancer Alkaloid Dimers Apocynaceae Extract
Target:
51
51 Cited Publications
Synonyms: MK-933; CD-5024; K-237
27
Category:
Human Gut Microbiota Metabolites Other disease Disease markers Endogenous metabolite Disease Research Fields Cancer Steroids
Target:
27
Target:
19
Target:
19
19 Cited Publications
Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β.
19
19 Cited Publications
Cat. No.: HY-P7425
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of Nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of Nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand Superfamily Member; ODF; Tumor Necrosis Factor Superfamily Member 11; Tumor Necrosis Factor Ligand Superfamily Member 11; Tumor Necrosis Factor Ligand 6B; TNF-Related Activation-Induced Cytokine; CD254 Antigen; Osteoclast Differentiation Factor; HRANKL2; Osteoprotegerin Ligand; OPTB2; CD254; SOdf
Species:
Mouse
Source:
E. coli
16
Category:
Cardiovascular Disease Serratula coronata Extract Plant Animal Compositae/Asteraceae Extract Other Families Extract Endogenous metabolite Disease Research Fields Steroids
Target:
13
13
13 Cited Publications
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Research Areas:
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .
13
Target:
Research Areas:
Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation . Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation . Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants . Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer .
11
Target:
11
11 Cited Publications
Cat. No.: HY-P7424
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of Nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of Nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:
Human
Source:
E. coli
10
10 Cited Publications
Target:
Research Areas:
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation . BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
10
10 Cited Publications
Research Areas:
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively .
7
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
6
6 Cited Publications
Synonyms: RAD140; EP0062
Target:
Research Areas:
Vosilasarm (RAD140) is a potent, orally active, nonsteroidal selective androgen receptor modulator (SARM) with a Ki of 7 nM. Vosilasarm shows good selectivity over other steroid hormone nuclear receptors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
