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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
OptoDArG
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "OptoDArG" in MCE Product Catalog:
Cat. No.: HY-126424
CAS No.: 2230617-93-1
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OptoDArG is a photoswitchable diacylglycerol analog that serves as an optical lipid clamp probe. OptoDArG undergoes rapid trans-cis photoisomerization under UV/blue light, with the trans form being inactive, and can be delivered directly to the cell membrane without genetic modification. Cis-OptoDArG regulates the activity of channels such as TRPC3, TRPC6, and TRPL by altering the properties of the cell membrane lipid bilayer, thereby triggering sodium channel-dependent action potentials, PKCα translocation, mechanically sensitive currents, and various other downstream electrophysiological and cellular effects. OptoDArG has activity in identifying lipid-gated pores by controlling TRPC3 channels, and can serve as a tool for studying the lipid-sensing mechanisms of TRPC channels .
Cat. No.: HY-P11446
CAS No.: 254729-66-3
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Cat. No.: HY-146127A
Purity: 99.71%
Cat. No.: HY-146127
CAS No.: 3069455-54-2
Cat. No.: HY-P10304C
CAS No.: 181961-24-0
Cat. No.: HY-P11446A
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Cat. No.: HY-P10304D
Cat. No.: HY-P11807
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Cat. No.: HY-P12338
Target:
Mitochondrial Metabolism STAT Reactive Oxygen Species (ROS) Amino Acid Derivatives Drug Derivative
Research Areas:
HNSS peptide is a chimeric hybrid peptide composed of the neuroprotective peptide S14G-Humanin and the mitochondria-targeted antioxidant peptide SS31. HNSS peptide is readily cleared in vivo and can be combined with nanocarriers to improve its stability. HNSS can be delivered via the FGFR1-targeting nanocarrier FGL-NP (Cit), ameliorating mitochondrial dysfunction, Aβ deposition, tau hyperphosphorylation, and cholinergic neuronal damage, and alleviating memory deficits in Alzheimer's disease mice. HNSS peptide is applicable for Alzheimer's disease-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
