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Tissue and Cell Fixative (4% Paraformaldehyde, PFA)

3 Cited Publications

Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is mainly composed of paraformaldehyde, phosphate, and deionized water, with a pH of 7.0-7.4. Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is suitable for fixing most tissues and cells, and can effectively protect the morphology and structure of tissues and cells as well as nucleic acids.

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1

MMV1557817

1 Cited Publications

Cat. No.: HY-163727

CAS No.: 2065197-82-0

Target:

Aminopeptidase Parasite

Research Areas:

Infection

MMV1557817 is an orally active dual aminopeptidase (Aminopeptidase) inhibitor. MMV1557817 targets multiple parasite life cycle stages by inhibiting M1 alanyl aminopeptidase and M17 leucyl aminopeptidase involved in terminal Hemoglobin (HY-P2995) digestion (PfA-M1 K_i = 269 nM; PfA-M17 K_i = 101 nM), exhibits broad cross-species antiplasmodial activity, and clears P. berghei infection in a mouse model. MMV1557817 can be used for research on malaria .

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(S)-Batylalcohol

Cat. No.: HY-169848

CAS No.: 6129-13-1

Synonyms: 1-O-Octadecyl-sn-glycerol

Target:

HIV

Research Areas:

Infection

(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is a phosphonoformic acid (PFA) analog that exhibits higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) than PFA. (S)-Batylalcohol can be used in antiretroviral research .

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Perfluoroundecanoic acid

Cat. No.: HY-W142432

CAS No.: 2058-94-8

Target:

β-catenin Wnt Arginase TGF-beta/Smad mTOR Akt ERK Atg8/LC3 p62 Autophagy

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .

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1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe

Cat. No.: HY-115701

CAS No.: 154436-49-4

Synonyms: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE

Target:

Ferroptosis

Research Areas:

Inflammation/Immunology

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

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