18

U-46619

18 Publications Verification

Cat. No.: HY-108566

CAS No.: 56985-40-1

Purity: ≥98.0%

Synonyms: 9,11-Methanoepoxy PGH2

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation .

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5

Cyanidin Chloride

5 Cited Publications

Cat. No.: HY-N0499

CAS No.: 528-58-5

Synonyms: IdB 1027

Category:

Anthocyans Flavonoids Anti-aging Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:

Free Radical Scavengers Prostaglandin Receptor

Cyanidin Chloride (IdB 1027) is an orally active antioxidant and enzyme inhibitor. Cyanidin Chloride has IC₅₀ values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin Chloride exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin Chloride can be used in the research of inflammatory diseases ^[2] .

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4

COX2 Antibody (YA493)

4 Cited Publications

Cat. No.: HY-P80091

Synonyms: PTGS2; COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.

Host:

Rabbit

Application:

WB, ICC/IF, IHC-P

Reactivity:

Human, Mouse, Rat

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3

Imidazole

3 Cited Publications

Cat. No.: HY-D0837

CAS No.: 288-32-4

Synonyms: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease ^[2] .

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3

COX-2 Protein, Human (sf9, His)

3 Cited Publications

Cat. No.: HY-P74222

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: PTGS2; Cyclooxygenase-2; Prostaglandin-Endoperoxide Synthase 2; PGH Synthase 2; Prostaglandin G/H Synthase 2; PGHS-2; COX2; Prostaglandin-Endoperoxidase Synthase 2; Prostaglandin H2 Synthase 2; Cyclooxygenase 2b; PHS II; GRIPGHS; COX-2; PGG/HS; Prostaglan

Species:

Human

Source:

Sf9 insect cells

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3

COX2 Antibody (YA791)

3 Cited Publications

Cat. No.: HY-P80090

Synonyms: COX2, PTGS2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, COX-2, PGH synthase 2, PGHS-2

Host:

Mouse

Application:

WB, IHC-P, FC

Reactivity:

Human, Mouse, Rat

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1

Ifetroban

1 Cited Publications

Cat. No.: HY-105218

CAS No.: 143443-90-7

Purity: 99.65%

Synonyms: BMS-180291

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research ^[2] .

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1

Ifetroban sodium

1 Cited Publications

Cat. No.: HY-105218A

CAS No.: 156715-37-6

Purity: 99.83%

Synonyms: BMS-180291 sodium

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research ^[2] .

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1

12S-HHT

1 Cited Publications

Cat. No.: HY-113330

CAS No.: 54397-84-1

Purity: 98.40%

Synonyms: 12(S)-HHTrE

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Leukotriene Receptor Endogenous Metabolite

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂ (PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity ^[2].

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Benoxaprofen

Cat. No.: HY-13568

CAS No.: 51234-28-7

Purity: 99.24%

Synonyms: LRCL 3794

Target:

Cytochrome P450 COX Lipoxygenase PGE synthase

Research Areas:

Inflammation/Immunology

Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms ^[2] .

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Darbufelone

Cat. No.: HY-101438

CAS No.: 139226-28-1

Synonyms: CI-1004

Target:

Prostaglandin Receptor Leukotriene Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Darbufelone is a dual inhibitor of cellular PGF_2α and LTB₄ production. Darbufelone potently inhibits PGHS-2 (IC₅₀= 0.19 μM) but is much less potent with PGHS-1 (IC₅₀=20 μM).

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Zaloglanstat

Cat. No.: HY-139589

CAS No.: 1513852-12-4

Purity: 98.50%

Synonyms: ISC-27864; GRC-27864

Target:

PGE synthase COX Collagen

Research Areas:

Neurological Disease Inflammation/Immunology

Zaloglanstat (ISC-27864; GRC-27864) is a selective, orally active microsomal mPGES-1 inhibitor. Zaloglanstat has an IC₅₀ of 5 nM for human mPGES-1 without significant inhibitory effect on COX-1/2 (IC₅₀ >10 μM). Zaloglanstat blocks the conversion of arachidonic acid metabolite prostaglandin PGH₂ to prostaglandin PGE₂, thereby inhibiting inflammation-related PGE₂ overproduction and reducing inflammatory responses and pain. Zaloglanstat inhibits IL-1β-induced PGE₂ release in A549 cells and human synovial fibroblasts in vitro. Zaloglanstat inhibits PGE2 release in pig and dog whole blood with IC₅₀s of 161 nM and 154 nM, respectively. Zaloglanstat can be used in the study of asthma, osteoarthritis, and neurodegenerative diseases ^[2] .

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