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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
PI3K catalytic subunit
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "PI3K catalytic subunit" in MCE Product Catalog:
18
1
1 Cited Publications
Cat. No.: HY-P80865
Synonyms: PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; p120-PI3K; PtdIns-3-kinase subunit p110-gamma; p110gamma; PIK3CG
Synonyms: DS11252927
Research Areas:
D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes .
Cat. No.: HY-N4259
CAS No.: 90985-77-6
Cat. No.: HY-163360
CAS No.: 885692-56-8
PI3Kα-IN-19 (Compound 1) is a PI3Kα inhibitor with a targeted binding site at the p110α catalytic subunit. PI3Kα is one of the most common dysregulated kinases used in cancer research .
Cat. No.: HY-10114R
CAS No.: 663619-89-4
Target:
Research Areas:
TGX-221 (Standard) is the analytical standard of TGX-221. This product is intended for research and analytical applications. TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment.
Cat. No.: HY-L015
1,168 compounds
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.
MCE owns a unique collection of 1,168 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.
Cat. No.: HY-P810808
Synonyms: PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; p110alpha; PIK3CA
Cat. No.: HY-P701752
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3C3; PtdIns-3-Kinase Type 3; Phosphatidylinositol 3-Kinase catalytic subunit Type 3; PI3-Kinase Type 3; HVps34; PI3K Type 3; Vps34; Phosphatidylinositol 3-Kinase, catalytic subunit Type 3; Phosphatidylinositol 3-Kinase P100 subunit; Phosphoinositide-3-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P83044
Synonyms: VPS34; PIK3C3; Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34
Cat. No.: HY-P86149
Synonyms: VPS34; PIK3C3; Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34
Cat. No.: HY-P88333
Synonyms: C2 PI3K; P3C2B_HUMAN; PI3K-C2-beta; PTDINS-3-kinase C2 beta; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphoinositide 3-Kinase class 2; beta; Phosphoinositide 3-Kinase-C2-beta; PtdIns-3-kinase C2 subunit beta; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase; catalytic subunit type 2 beta; phosphoinositide-3-kinase; class 2; beta polypeptide
Cat. No.: HY-P88333A
Synonyms: C2 PI3K; P3C2B_HUMAN; PI3K-C2-beta; PTDINS-3-kinase C2 beta; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphoinositide 3-Kinase class 2; beta; Phosphoinositide 3-Kinase-C2-beta; PtdIns-3-kinase C2 subunit beta; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase; catalytic subunit type 2 beta; phosphoinositide-3-kinase; class 2; beta polypeptide
Cat. No.: HY-P87775
Synonyms: PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; p120-PI3K; PtdIns-3-kinase subunit p110-gamma; p110gamma; PIK3CG
Cat. No.: HY-P81162
Synonyms: PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; p110alpha; PIK3CA
Cat. No.: HY-P703582
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; EC:2.7.1.137; EC:2.7.1.153; EC:2.7.1.154; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kD
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P81162A
Synonyms: PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; p110alpha; PIK3CA
Cat. No.: HY-P86078
Synonyms: PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; p110alpha; PIK3CA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
