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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
PKR1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "PKR1" in MCE Product Catalog:
58
Target:
Research Areas:
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR .
Synonyms: PKRA7
Target:
Research Areas:
PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. [1] .
Cat. No.: HY-159972
CAS No.: 910113-60-9
Target:
Research Areas:
PKR1 antagonist 1 (PC1) is a potent PKR1 antagonist. PKR1 antagonist 1 reduces hyperalgesia and allodynia in SNI mice [1].
Cat. No.: HY-153201
CAS No.: 910113-34-7
Research Areas:
PKR1 antagonist-2 is a non-peptide prokineticin receptor antagonist that preferentially binds to and blocks PK-R1 signaling while also blocking PK-R2. PKR1 antagonist-2 shifts the autoimmune response against myelin from a Th1/Th17 profile toward a Th2 profile, reducing myelin antigen-specific T cell proliferation and the production of proinflammatory cytokines (IFN-γ, TNF, IL-6, IL-17), and increasing the levels of anti-inflammatory cytokines IL-4/IL-10. PKR1 antagonist-2 significantly alleviates disease severity in relapsing-remitting and chronic experimental autoimmune encephalomyelitis (EAE). PKR1 antagonist-2 can be used in research related to multiple sclerosis [1].
Cat. No.: HY-125807
CAS No.: 324561-95-7
Target:
G Protein-coupled Receptor Kinase (GRK) Apoptosis Reactive Oxygen Species (ROS) Akt p38 MAPK
Research Areas:
IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and ROS production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research [1].
Cat. No.: HY-147056B
Synonyms: PKRA7 hydrochloride
Target:
Research Areas:
PKRA83 (PKRA7) hydrochloride is a potent PK2 antagonist that competes for PK2 binding to its receptors, PKR1 and PKR2. PKRA83 hydrochloride potently inhibits PK2 receptors with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 hydrochloride exhibits anticancer, antiarthritis, and antiangiogenic activities [1].
Cat. No.: HY-RS11196
Target:
Research Areas:
PROKR1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROKR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P82006A
Synonyms: PRKAR1A; PKR1; PRKAR1; TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1
Cat. No.: HY-P75982
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAR1A; Carney Complex Type 1; Prev. PRKAR1; CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Chain; Prev. PKR1; CAMP-Dependent Protein Kinase Regulatory Subunit RIalpha; Prev. TSE1; Epididymis Secretory Sperm Binding Protein; Prev. Prkar1alpha; Tis
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-RS11112
Target:
Research Areas:
PRKAR1A Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAR1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71103
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAR1A; Carney Complex Type 1; Prev. PRKAR1; CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Chain; Prev. PKR1; CAMP-Dependent Protein Kinase Regulatory Subunit RIalpha; Prev. TSE1; Epididymis Secretory Sperm Binding Protein; Prev. Prkar1alpha; Tis
Species:
Human
Source:
HEK293
Cat. No.: HY-18657R
CAS No.: 1221186-53-3
Synonyms: ML-265 (Standard)
Target:
Research Areas:
TEPP-46 (Standard) is the analytical standard of TEPP-46 (HY-18657). This product is intended for research and analytical applications. TEPP-46 (ML-265) is a potent and selective pyruvate Kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
