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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
PMM
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "PMM" in MCE Product Catalog:
Synonyms: REN001; HPP593
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Mavodelpar (REN001) is a selective PPARδ agonist. Mavodelpar suppresses glomerular injury and renal fibrosis. Mavodelpar can be used for the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD) . Mavodelpar is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: ASP0367; MA-0211
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Bocidelpar (ASP0367; MA-0211) is a selective, orally active PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD) .
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Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .
Cat. No.: HY-N8365
CAS No.: 91183-87-8
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Cat. No.: HY-RS10766
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PMM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10767
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PMM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19630
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Pmm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pmm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26125
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Pmm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pmm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113002
CAS No.: 10139-18-1
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α-D-Glucose 1,6-bisphosphate is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome) .
Cat. No.: HY-113002A
CAS No.: 71662-13-0
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α-D-Glucose 1,6-bisphosphate cyclohexanamine is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate cyclohexanamine regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate cyclohexanamine can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome) .
Cat. No.: HY-186330
CAS No.: 2763421-81-2
Synonyms: PMMB-302
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PMM-302 (PMMB-302) is a shikonin N-benzyl sophoridate derivative and a telomerase inhibitor. PMM-302 downregulates the telomerase core proteins DKC1 and NHP2 as well as TERT mRNA, and inhibits telomerase activity. PMM-302 induces G2/M phase cell cycle arrest and apoptosis, accompanied by downregulation of Bcl2, Bcl-XL, and FADD and upregulation of cleaved caspase-3 and cleaved caspase-9. PMM-302 can be used for lung cancer-related research .
Category:
Alkaloids Piperidine Alkaloids Triclisia gilletii (De Wild.) Staner Menispermaceae Extract Plants
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Cat. No.: HY-RS19368
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Pmm2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pmm2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25860
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Pmm2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pmm2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71021
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PMM2; PMI; Prev. CDG1; Phosphomannose Isomerase 1; CDG1a; PMM 2; PMI1; Congenital Disorder Of Glycosylation, Type Ia; CDGS; Phosphomannomutase; Phosphomannomutase 2; Mannose-6-Phosphate Isomerase
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
