13

PP1

13 Cited Publications

Cat. No.: HY-13804

CAS No.: 172889-26-8

Purity: 99.19%

Synonyms: AGL 1872; EI 275

Target:

Src Apoptosis

Research Areas:

Cancer

PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC₅₀ of 5 and 6 nM for Lck and Fyn, respectively.

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26

Okadaic acid

26 Publications Verification

Cat. No.: HY-N6785

CAS No.: 78111-17-8

Category:

Animals Ketones, Aldehydes, Acids Marine natural products Other marine organisms

Target:

Phosphatase Apoptosis

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation ^[1] .

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26

Okadaic acid sodium

26 Publications Verification

Cat. No.: HY-N6785A

CAS No.: 209266-80-8

Target:

Phosphatase Apoptosis

Research Areas:

Neurological Disease Cancer

Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation ^[1] .

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26

Okadaic acid ammonium salt

26 Publications Verification

Cat. No.: HY-115760

CAS No.: 175522-42-6

Target:

Phosphatase

Research Areas:

Neurological Disease Cancer

Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation ^[1] .

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20

Calyculin A

20 Cited Publications

Cat. No.: HY-18983

CAS No.: 101932-71-2

Synonyms: (-)-Calyculin A

Target:

Phosphatase

Research Areas:

Cancer

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 2 nM and 0.5-1 nM, respectively ^[1].

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9

DCP-LA

9 Cited Publications

Cat. No.: HY-108599

CAS No.: 28399-31-7

Purity: ≥98.0%

Synonyms: FR236924

Target:

PKC CaMK Phosphatase Apoptosis

Research Areas:

Neurological Disease

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( ²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis ^[1] .

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8

1-NM-PP1

8 Cited Publications

Cat. No.: HY-13942

CAS No.: 221244-14-0

Purity: 99.17%

Synonyms: PP1 Analog II

Target:

Src

Research Areas:

Cancer

1-NM-PP1, a cell-permeable PP1 analog, is a potent Src family kinases inhibitor with IC₅₀s of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively ^[1] .

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4

Raphin1

4 Cited Publications

Cat. No.: HY-123960

CAS No.: 2022961-17-5

Purity: 99.75%

Target:

Phosphatase

Research Areas:

Neurological Disease

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (K_d=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease ^[1].

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4

Raphin1 acetate

4 Cited Publications

Cat. No.: HY-123960A

CAS No.: 2242616-04-0

Purity: 99.93%

Target:

Phosphatase

Research Areas:

Neurological Disease

Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (K_d=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease ^[1].

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3

1-Naphthyl PP1

3 Cited Publications

Cat. No.: HY-13941

CAS No.: 221243-82-9

Purity: 98.96%

Synonyms: 1-NA-PP 1

Target:

Src PKD

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively ^[1] .

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3

1-Naphthyl PP1 hydrochloride

3 Cited Publications

Cat. No.: HY-13941B

CAS No.: 956025-47-1

Purity: 99.83%

Synonyms: 1-NA-PP 1 hydrochloride

Target:

Src PKD

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively ^[1] .

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2

C2 Ceramide

2 Cited Publications

Cat. No.: HY-101180

CAS No.: 3102-57-6

Purity: 99.85%

Synonyms: Ceramide 2

Target:

Phosphatase Mitochondrial Metabolism Apoptosis Autophagy

Research Areas:

Metabolic Disease Endocrinology

C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss ^[1] .

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1

3MB-PP1

1 Cited Publications

Cat. No.: HY-102069

CAS No.: 956025-83-5

Purity: 99.66%

Target:

Polo-like Kinase (PLK) CDK DAPK

Research Areas:

Others

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC₅₀=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division ^[1] .

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