33

Omadacycline

33 Publications Verification

Cat. No.: HY-14865

CAS No.: 389139-89-3

Purity: 99.85%

Synonyms: PTK 0796; Amadacycline

Target:

Bacterial Antibiotic

Research Areas:

Infection

Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

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33

Omadacycline tosylate

33 Publications Verification

Cat. No.: HY-14865B

CAS No.: 1075240-43-5

Purity: 99.37%

Synonyms: PTK 0796 tosylate; Amadacycline tosylate

Target:

Bacterial Antibiotic

Research Areas:

Infection

Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

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33

Omadacycline hydrochloride

33 Publications Verification

Cat. No.: HY-14865C

CAS No.: 1196800-39-1

Purity: 99.47%

Synonyms: PTK0796 hydrochloride; Amadacycline hydrochloride

Target:

Bacterial Antibiotic

Research Areas:

Infection

Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

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15

Vatalanib

15 Cited Publications

Cat. No.: HY-10203

CAS No.: 212141-54-3

Purity: 99.93%

Synonyms: PTK787; ZK-222584; CGP-79787

Target:

VEGFR

Research Areas:

Cancer

Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC₅₀ of 37 nM.

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15

Vatalanib dihydrochloride

15 Cited Publications

Cat. No.: HY-12018

CAS No.: 212141-51-0

Purity: 99.68%

Synonyms: PTK787 dihydrochloride; ZK-222584 dihydrochloride; CGP-797870 dihydrochloride

Target:

VEGFR Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Vatalanib dihydrochloride (PTK787 dihydrochloride) is a BBB-permeable VEGFR2/KDR inhibitor with an IC₅₀ of 37 nM.

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2

Phospho-FAK (Tyr397) Antibody (YA198)

2 Cited Publications

Cat. No.: HY-P80460

Synonyms: FAK, FAK1, PTK2, Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FRNK, PPP1R71

Host:

Rabbit

Application:

WB, ICC/IF

Reactivity:

Human, Mouse

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1

BI-3663

1 Cited Publications

Cat. No.: HY-111546

CAS No.: 2341740-84-7

Purity: 99.84%

Target:

PROTACs FAK

Research Areas:

Cancer

BI-3663 is a highly selective PTK2/FAK PROTAC (DC₅₀ = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC₅₀ value of 18 nM. BI-3663 is a PROTAC generated by linking the PTK2/FAK inhibitor BI-4464 (HY-124625) with a Pomalidomide (HY-10984) derivative via a linker. BI-3663 can induce PTK2 degradation at low nanomolar concentrations. BI-3663 has antitumor activity .

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1

PTK7 Protein, Rat (HEK293, His)

1 Cited Publications

Cat. No.: HY-P78619

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: PTK7; PTK7 Protein Tyrosine Kinase 7; Protein Tyrosine Kinase 7 (Inactive); Tyrosine-Protein Kinase-Like 7; CCK4; CCK-4; Colon Carcinoma Kinase 4; Protein Tyrosine Kinase 7; Inactive Tyrosine-Protein Kinase 7; Protein-Tyrosine Kinase 7; Pseudo Tyrosine Ki

Species:

Rat

Source:

HEK293

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1

PTK7 Protein, Mouse (HEK293, His)

1 Cited Publications

Cat. No.: HY-P78761

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: PTK7; PTK7 Protein Tyrosine Kinase 7; Protein Tyrosine Kinase 7 (Inactive); Tyrosine-Protein Kinase-Like 7; CCK4; CCK-4; Colon Carcinoma Kinase 4; Protein Tyrosine Kinase 7; Inactive Tyrosine-Protein Kinase 7; Protein-Tyrosine Kinase 7; Pseudo Tyrosine Ki

Species:

Mouse

Source:

HEK293

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1

Tyrphostin A51

1 Cited Publications

Cat. No.: HY-101960A

CAS No.: 126433-07-6

Purity: ≥99.0%

Synonyms: AG-183

Target:

EGFR

Research Areas:

Cancer

Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

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1

TL12-186

1 Cited Publications

Cat. No.: HY-130665

CAS No.: 2250025-88-6

Purity: 99.63%

Target:

PROTACs CDK FLT3 Btk Aurora Kinase Itk Wee1 JAK

Research Areas:

Cancer

TL12-186 is a multi-kinase PROTAC degrader. TL12-186 recruits the CRBN E3 ubiquitin ligase to target and degrade a variety of distinct kinases, including FLT3, BTK, AURKA, PTK2B, and multiple cyclin-dependent kinases (CDKs). TL12-186 can be used in leukemia-related research .

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1

FAK Antibody (YA6263)

1 Cited Publications

Cat. No.: HY-P86571

Synonyms: PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:

Human, Mouse, Rat

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Cofetuzumab pelidotin

Cat. No.: HY-P99829

CAS No.: 1869937-48-3

Synonyms: PF-06647020; ABBV-647; h6M24-vc0101

Target:

Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin

Research Areas:

Cancer

Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

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Cofetuzumab

Cat. No.: HY-P99828

CAS No.: 1869928-62-0

Synonyms: PF-06523435; hu24

Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .

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Tilfrinib

Cat. No.: HY-110244

CAS No.: 1600515-49-8

Purity: 99.69%

Target:

BRK

Research Areas:

Cancer

Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC₅₀ value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour .

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MS105

Cat. No.: HY-171830

CAS No.: 2408339-39-7

Synonyms: YX39-105

Target:

PROTACs Tyrosinase Apoptosis

Research Areas:

Cancer

MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) (BRK) PROTAC degrader. MS105 recruits VHL E3 ligase via a VHL ligand moiety, promotes PTK6 ubiquitination and proteasomal degradation, inhibits the proliferation and migration of breast cancer cells, and induces apoptosis. MS105 shows potential for use in breast cancer research .

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BI-4464

Cat. No.: HY-124625

CAS No.: 1227948-02-8

Purity: 98.64%

Target:

FAK Target Protein Ligand-Linker Conjugates

Research Areas:

Infection Cancer

BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC₅₀ value of 17 nM. BI-4464 is a FAK (HY-43760) ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467). PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader .

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