14

PAP-1

14 Publications Verification

Cat. No.: HY-10015

CAS No.: 870653-45-5

Purity: 99.83%

Synonyms: 5-(4-Phenoxybutoxy)psoralen

Target:

Potassium Channel

Research Areas:

Inflammation/Immunology

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC₅₀=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC₅₀=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .

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4

Pyropheophorbide-a

4 Cited Publications

Cat. No.: HY-128973

CAS No.: 24533-72-0

Purity: ≥98.0%

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Cancer

Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells .

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3

BMS-195614

3 Cited Publications

Cat. No.: HY-101259

CAS No.: 182135-66-6

Purity: 99.5%

Synonyms: BMS 614

Target:

RAR/RXR Bcl-2 Family NF-κB PPAR VEGFR Interleukin Related

Research Areas:

Cardiovascular Disease Inflammation/Immunology Endocrinology

BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a K_i of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis .

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Benoxaprofen

Cat. No.: HY-13568

CAS No.: 51234-28-7

Purity: 99.24%

Synonyms: LRCL 3794

Target:

Cytochrome P450 COX Lipoxygenase PGE synthase

Research Areas:

Inflammation/Immunology

Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .

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para-Nitroblebbistatin

Cat. No.: HY-120870

CAS No.: 1621326-32-6

Purity: ≥99.0%

Synonyms: (-)-para-Nitroblebbistatin

Target:

Myosin

Research Areas:

Others

para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology .

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Flipper-TR 5

Cat. No.: HY-D2318

CAS No.: 2081888-04-0

Flipper-TR 5 is a Flipper probe containing a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 selectively labels the cytoplasmic membrane, and exhibits excellent mechanical sensitivity, negligible cytotoxicity and controllable phototoxicity .

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