Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Pol I
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Pol I" in MCE Product Catalog:
15
15 Publications Verification
Target:
Research Areas:
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .
10
Target:
Research Areas:
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template .
3
3 Cited Publications
Cat. No.: HY-P77587
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Mouse
Source:
HEK293
Synonyms: ML246
Target:
Research Areas:
Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models .
Target:
Research Areas:
POL1-IN-1 is a class of RNA polymerase I inhibitors with broad-spectrum antiproliferative activity against tumor cells, while selectively inhibiting RNA polymerase I transcription. By blocking RNA polymerase I-mediated rRNA synthesis, POL1-IN-1 impairs ribosome biogenesis, thereby inhibiting tumor cell proliferation and inducing apoptosis. POL1-IN-1 can be used for the research of malignant tumors .
Cat. No.: HY-118723
CAS No.: 309726-06-5
Target:
Research Areas:
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .
Cat. No.: HY-145840
CAS No.: 2765318-69-0
Target:
Research Areas:
Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194 .
Cat. No.: HY-P71702
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
E. coli
Cat. No.: HY-P7708A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
E. coli
Cat. No.: HY-P7707
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
HEK293
Cat. No.: HY-P77586
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
HEK293
Cat. No.: HY-P7708
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
E. coli
Cat. No.: HY-P700614
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Human
Source:
P. pastoris
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
