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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Protoporphyrin IX
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Protoporphyrin IX" in MCE Product Catalog:
24
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Microorganism Endogenous metabolite Disease Research Fields
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71
71 Publications Verification
Synonyms: Zn(II)-Protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9
24
24 Cited Publications
Synonyms: Tin-Protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
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Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .
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Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .
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22 Cited Publications
Synonyms: 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride
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22
22 Cited Publications
Cat. No.: HY-W000450
CAS No.: 106-60-5
Synonyms: 5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid
Category:
Cardiovascular Disease Amino acids Endogenous metabolite Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Disease markers Microorganism Disease Research Fields Cancer
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4
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Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia) .
1
1 Cited Publications
Cat. No.: HY-W250116
CAS No.: 102601-60-5
Synonyms: Protoporphyrin IX cobaltic chloride; CoPPIX-Cl
1
1 Cited Publications
Cat. No.: HY-A0169A
CAS No.: 79416-27-6
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Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .
Cat. No.: HY-134608
CAS No.: 14325-03-2
Synonyms: Co-PPIX
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Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .
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Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species .
Cat. No.: HY-136476
CAS No.: 14947-11-6
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Mg (II) protoporphyrin IX is a precursor of chlorophyll in Chlorella. Mg (II) protoporphyrin IX acts as a negative effector of nuclear photosynthetic gene expression. Mg (II) protoporphyrin IX can be used to study signal molecules involved in plastid-nucleus communication .
Synonyms: V-53482
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Flumioxazin (V-53482) is a protoporphyrinogen IX oxidase (PPO) inhibitor with a rat target IC50 of 4.58 nM. Flumioxazin is found in its biological sources and is used for pre-emergence control of dicotyledonous weeds in soybean and peanut. Flumioxazin inhibits protoporphyrinogen oxidase, blocking chlorophyll and heme biosynthesis, leading to protoporphyrin IX accumulation, oxidative stress, membrane damage, and cell death. Flumioxazin is used in research on weed control .
Cat. No.: HY-W854721
CAS No.: 120389-54-0
Synonyms: Manganese(III) Protoporphyrin IX Chloride
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Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.
Cat. No.: HY-101193R
CAS No.: 15442-64-5
Synonyms: Zn(II)-Protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)
Cat. No.: HY-136476A
CAS No.: 21393-64-6
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Mn(II) protoporphyrin IX is a potential intravenous paramagnetic magnetic resonance contrast agent. Mn(II) protoporphyrin IX maintains strong paramagnetic properties .
Cat. No.: HY-136476C
CAS No.: 15415-30-2
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Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase .
Synonyms: Benzyl-ALA hydrochloride
Research Areas:
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines .
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Pt(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
