3

(R)-CR8

3 Cited Publications

Cat. No.: HY-18340

CAS No.: 294646-77-8

Synonyms: CR8, (R)-isomer

Target:

Molecular Glues CDK Apoptosis

Research Areas:

Neurological Disease Cancer

(R)-CR8, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .

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3

(R)-CR8 trihydrochloride

3 Cited Publications

Cat. No.: HY-18340A

CAS No.: 1786438-30-9

Synonyms: CR8, (R)-isomer trihydrochloride

Target:

Molecular Glues CDK Apoptosis

Research Areas:

Neurological Disease Cancer

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect . (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K .

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2

(-)-Isoproterenol hydrochloride

2 Cited Publications

Cat. No.: HY-B1670A

CAS No.: 5984-95-2

Synonyms: Levisoprenaline hydrochloride; Proternol L hydrochloride

Target:

Caspase TNF Receptor

Research Areas:

Metabolic Disease

(-)-Isoproterenol (Levisoprenalinel) hydrochloride is the R-isomer of Isoproterenol. (-)-Isoproterenol hydrochloride can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol hydrochloride can be used for the study of diabetic retinopathy .

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2

ICRF-193

2 Cited Publications

Cat. No.: HY-118590

CAS No.: 21416-88-6

Purity: 99.64%

Target:

Topoisomerase DNA/RNA Synthesis Apoptosis Fungal

Research Areas:

Infection Cardiovascular Disease Inflammation/Immunology Cancer

ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .

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2

(R)-NVS-ZP7-4

2 Cited Publications

Cat. No.: HY-114395A

CAS No.: 2517682-14-1

Purity: 98.80%

Target:

Drug Isomer

Research Areas:

Inflammation/Immunology

(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.

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