223

Metformin

223 Publications Verification

Cat. No.: HY-B0627

CAS No.: 657-24-9

Synonyms: 1,1-Dimethylbiguanide

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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223

Metformin hydrochloride

223 Publications Verification

Cat. No.: HY-17471A

CAS No.: 1115-70-4

Synonyms: 1,1-Dimethylbiguanide hydrochloride

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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10

GGTI298 Trifluoroacetate

10 Cited Publications

Cat. No.: HY-15871

CAS No.: 1217457-86-7

Purity: 99.61%

Target:

Apoptosis

Research Areas:

Cancer

GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC₅₀ of 3 μM; little effect on Ha-Ras with IC₅₀ of >20 μM.

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6

RAGE antagonist peptide

6 Cited Publications

Cat. No.: HY-P2268

CAS No.: 1092460-91-7

Target:

Amyloid-β

Research Areas:

Inflammation/Immunology Cancer

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities .

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2

LRPAP1 Protein, Mouse (HEK293, His)

2 Cited Publications

Cat. No.: HY-P76479A

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1; Prev. RAP; 39 KDa Receptor-Associated Protein

Species:

Mouse

Source:

HEK293

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2

LRPAP1 Protein, Mouse (HEK293, His, Solution)

2 Cited Publications

Cat. No.: HY-P76479

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1; Prev. RAP; 39 KDa Receptor-Associated Protein

Species:

Mouse

Source:

HEK293

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2

LRPAP1 Protein, Human (HEK293, C-His)

2 Cited Publications

Cat. No.: HY-P76478A

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1; Prev. RAP; 39 KDa Receptor-Associated Protein

Species:

Human

Source:

HEK293

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1

Sotatercept (mIgG2a)

1 Cited Publications

Cat. No.: HY-P99590A

Synonyms: RAP-011

Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

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1

HJC0197

1 Cited Publications

Cat. No.: HY-117958

CAS No.: 1383539-73-8

Purity: 99.62%

Target:

Ras

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

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1

8-pCPT-2'-O-Me-cAMP-AM

1 Cited Publications

Cat. No.: HY-107544

CAS No.: 1152197-23-3

Target:

PKA

Research Areas:

Metabolic Disease

8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway .

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1

GGTI-2133

1 Cited Publications

Cat. No.: HY-12369

CAS No.: 191102-79-1

Purity: 98.50%

Target:

GGTase

Research Areas:

Inflammation/Immunology

GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma .

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1

8-pCPT-2′-O-Me-cAMP sodium

1 Cited Publications

Cat. No.: HY-107543

CAS No.: 634207-53-7

Purity: 99.81%

Synonyms: 8-CPT-2'-O-Me-cAMP sodium

Target:

Ras

Research Areas:

Cardiovascular Disease

8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀ >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca ²⁺ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .

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