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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
186 Results for "
RAW 264.7
" in MedChemExpress (MCE) Product Catalog:
Products (186)
186 Results for "RAW 264.7" in MCE Product Catalog:
165
165 Publications Verification
Target:
Research Areas:
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
8
8 Cited Publications
ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers .
4
4 Cited Publications
Cat. No.: HY-N0617
CAS No.: 80651-76-9
Category:
Cardiovascular Disease Moraceae Extract Morus alba Linn. Extract Flavanonols Plant Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology
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3
3 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
2
Category:
Plant Coumarins Cimicifuga racemosa (L.) Nutt. Extract Phenylpropanoids Disease Research Fields Inflammation/Immunology Ranunculaceae Extract
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2
2
2 Cited Publications
Cat. No.: HY-W082785A
CAS No.: 24533-47-9
Target:
TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
2
2
2 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
1
1 Cited Publications
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Category:
Plant Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Other Families Extract Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Cat. No.: HY-N0569R
CAS No.: 18449-41-7
1
Category:
Plant Cyperaceae Extract Terpenoids Sesquiterpenes Cyperus rotundus L. Extract Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
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T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
1
1 Cited Publications
Cat. No.: HY-N7012
CAS No.: 29080-58-8
Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone
Cat. No.: HY-N3383
CAS No.: 35897-92-8
Synonyms: Ligstroside
Category:
Ligustrum japonicum Thunb. Extract Plant Monophenols Iridoids Terpenoids Phenols Oleaceae Extract
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Category:
Quinones Plant Monophenols Anthraquinones Phenols Damnacanthus major Sieb. et Zucc. Extract Rubiaceae Extract
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Cat. No.: HY-171274
CAS No.: 149775-26-8
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DOCK5-IN-1 (Compound 14) is the inhibitor for DOCK5 and exhibits no toxicity (100 μM) in cell RAW264.7 .
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Research Areas:
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .
Cat. No.: HY-W753791
CAS No.: 2111-75-3
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Research Areas:
(±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM .
Cat. No.: HY-N0223
CAS No.: 38736-77-5
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
