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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
ROC
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "ROC" in MCE Product Catalog:
34
4
4 Cited Publications
ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis .
1
1 Cited Publications
Target:
Research Areas:
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively .
Target:
Research Areas:
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .
Cat. No.: HY-N15737
CAS No.: 50982-40-6
Target:
Cat. No.: HY-19356B
CAS No.: 1699754-37-4
Research Areas:
(+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .
Cat. No.: HY-103706R
CAS No.: 1859141-26-6
Target:
Research Areas:
ROC-325 (Standard) is the analytical standard of ROC-325 (HY-103706). This product is intended for research and analytical applications. ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis .
Cat. No.: HY-N15735
CAS No.: 219986-51-3
Synonyms: 2-Caffeoylpiscidic acid
Target:
Cat. No.: HY-P87951
Synonyms: RNF75; ROC1; RBX1; E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Regulator of cullins 1; Rbx1
Cat. No.: HY-P81379A
Synonyms: RNF75; ROC1; RBX1; E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Regulator of cullins 1; Rbx1
Cat. No.: HY-P702790
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF7; Sensitive To Apoptosis Zinc RING Finger Protein SAG; Ring Finger Protein 7; Sensitive To Apoptosis Gene Protein; CKBBP1; CKII Beta-Binding Protein 1; ROC2; Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2; RBX2; Zinc RING
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P702791
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF7; Sensitive To Apoptosis Zinc RING Finger Protein SAG; Ring Finger Protein 7; Sensitive To Apoptosis Gene Protein; CKBBP1; CKII Beta-Binding Protein 1; ROC2; Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2; RBX2; Zinc RING
Species:
Human
Source:
E. coli
Cat. No.: HY-P703245
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CUL3; Uncharacterized Protein CUL3; Cullin 3; KIAA0617; Cullin-3; NEDAUS; CUL-3; PHA2E; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of Cull
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705629
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CUL2; CUL-2; Cullin 2; Testis Secretory Sperm-Binding Protein Li 238E; Cullin-2; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of Cullins 1;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703246
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CUL4A; CUL-4A; Cullin 4A; Cullin-4B; Cullin-4A; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of Cullins 1; ZYP Protein; BA554C12.1; Protein
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
