10837 Results for "

Rat subcutaneous model

" in MedChemExpress (MCE) Product Catalog:

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327

Selisistat

327 Publications Verification

Cat. No.: HY-15452

CAS No.: 49843-98-3

Purity: 99.85%

Synonyms: EX-527

Target:

Sirtuin

Research Areas:

Inflammation/Immunology Cancer

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

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323

Sorafenib

323 Cited Publications

Cat. No.: HY-10201

CAS No.: 284461-73-0

Purity: 99.92%

Synonyms: Bay 43-9006

Target:

Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family Ephrin Receptor PDGFR

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .

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323

Sorafenib tosylate

323 Cited Publications

Cat. No.: HY-10201A

CAS No.: 475207-59-1

Purity: 99.75%

Synonyms: Bay 43-9006 tosylate

Target:

Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sorafenib (Bay 43-9006) tosylate is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib tosylate induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib tosylate inhibits tumor growth and metastasis in mouse and rat models. Sorafenib tosylate can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .

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202

Doxycycline hydrochloride

202 Cited Publications

Cat. No.: HY-N0565A

CAS No.: 10592-13-9

Target:

MMP Bacterial Antibiotic Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .

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202

Doxycycline hyclate

202 Cited Publications

Cat. No.: HY-N0565B

CAS No.: 24390-14-5

Synonyms: Doxycycline hydrochloride hemiethanolate hemihydRate; WC2031

Target:

Antibiotic MMP Bacterial Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .

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162

Streptozotocin

162 Cited Publications

Cat. No.: HY-13753

CAS No.: 18883-66-4

Purity: 99.20%

Synonyms: Streptozocin; NSC-85998; U 9889

Category:

Microorganisms Antibiotics Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .

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128

Palmitic acid

128 Cited Publications

Cat. No.: HY-N0830

CAS No.: 57-10-3

Category:

Cardiovascular Disease Natural Products Neurological Disease Plants Other Families Extract Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms Animals Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite HSP

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .

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128

Palmitic acid sodium

128 Cited Publications

Cat. No.: HY-N0830B

CAS No.: 408-35-5

Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

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MPTP hydrochloride

96 Cited Publications

Cat. No.: HY-15608

CAS No.: 23007-85-4

Purity: 99.52%

Target:

Dopamine Receptor Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology

MPTP hydrochloride is a brain penetrant dopaminergic neurotoxin. MPTP hydrochloride can be used to induce Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP ⁺, induces apoptosis . MPTP hydrochloride has been verified by MCE with professional biological experiments.

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MPTP

96 Cited Publications

Cat. No.: HY-W114750

CAS No.: 28289-54-5

Target:

Dopamine Receptor Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology

MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP ⁺, induces apoptosis .

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L-NAME hydrochloride

90 Cited Publications

Cat. No.: HY-18729A

CAS No.: 51298-62-5

Synonyms: NG-Nitroarginine methyl ester hydrochloride

Target:

NO Synthase

Research Areas:

Infection Neurological Disease Cancer

L-NAME hydrochloride inhibits NOS with an IC₅₀ of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC₅₀ value of 1.4 μM. L-NAME hydrochloride requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor. L-NAME hydrochloride can be used to induce hypertension and preeclampsia models.

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Acetaminophen

78 Cited Publications

Cat. No.: HY-66005

CAS No.: 103-90-2

Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

Category:

Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

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TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)

76 Cited Publications

Cat. No.: HY-P7117

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; CamuRati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;

Species:

Rat Mouse

Source:

HEK293

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666-15

67 Cited Publications

Cat. No.: HY-101120

CAS No.: 1433286-70-4

Purity: 99.74%

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

666-15 is a potent and selective CREB inhibitor with an IC₅₀ of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model .

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Dizocilpine maleate

53 Cited Publications

Cat. No.: HY-15084

CAS No.: 77086-22-7

Purity: 99.99%

Synonyms: (+)-MK 801 Maleate

Target:

iGluR

Research Areas:

Neurological Disease

Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with K_d of 37.2 nM in rat brain membranes.

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