42

42 Publications Verification

Target:

Research Areas:

A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀ values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.

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20

CAY10566

20 Cited Publications

Cat. No.: HY-15823

CAS No.: 944808-88-2

Purity: 99.93%

Target:

Stearoyl-CoA Desaturase (SCD)

Research Areas:

Cancer

CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC₅₀=7.9 nM or 6.8 nM) ^[1] .

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9

E6446 dihydrochloride

9 Cited Publications

Cat. No.: HY-12756A

CAS No.: 1345675-25-3

Purity: 99.96%

Target:

Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease Inflammation/Immunology

E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) ^[1] .

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9

E6446

9 Cited Publications

Cat. No.: HY-12756

CAS No.: 1219925-73-1

Purity: ≥98.0%

Target:

Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease Inflammation/Immunology

E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) ^[1] .

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7

MF-438

7 Cited Publications

Cat. No.: HY-15822

CAS No.: 921605-87-0

Purity: 99.83%

Target:

Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC₅₀ of 2.3 nM for rSCD1 ^[1].

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4

MK-8245

4 Cited Publications

Cat. No.: HY-13070

CAS No.: 1030612-90-8

Purity: 99.04%

Target:

Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease

MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC₅₀s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy ^[1].

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4

MK-8245 Trifluoroacetate

4 Cited Publications

Cat. No.: HY-13077

CAS No.: 1415559-41-9

Purity: 98.45%

Target:

Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease

MK-8245 Trifluoroacetate is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC₅₀s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy ^[1].

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2

Osivelotor

2 Cited Publications

Cat. No.: HY-148788

CAS No.: 2417955-18-9

Purity: 99.83%

Synonyms: GBT-601; GBT-021601

Target:

Hemoglobin

Research Areas:

Others

Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .

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1

SSI-4

1 Cited Publications

Cat. No.: HY-155033

CAS No.: 1875084-68-6

Purity: 99.95%

Target:

Stearoyl-CoA Desaturase (SCD) DNA/RNA Synthesis Apoptosis Autophagy mTOR Influenza Virus

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

SSI-4 is an orally active stearoyl-CoA desaturase (SCD1) inhibitor with an EC₅₀ of 1.9 nM against mouse SCD1. SSI-4 blocks the conversion of saturated fatty acids to monounsaturated fatty acids, reducing the production of oleic acid and palmitoleic acid. SSI-4 induces lipid peroxidation, endoplasmic reticulum stress, DNA damage and activates apoptotic mechanisms. SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. SSI-4 is applicable to research on cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections ^[1] .

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1

Icomidocholic acid

1 Cited Publications

Cat. No.: HY-19796

CAS No.: 246529-22-6

Synonyms: Aramchol; C20-FABAC

Target:

Stearoyl-CoA Desaturase (SCD)

Research Areas:

Metabolic Disease

Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) ^[1] .

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