54 Results for "

SHIV C2/1

" in MedChemExpress (MCE) Product Catalog:
Products (54)

54 Results for "SHIV C2/1" in MCE Product Catalog:

7
7 Publications Verification
Cat. No.: HY-100113
CAS No.: 477775-14-7
Purity:  99.02%
Synonyms: AT2 receptor agonist C21
Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .
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1 Cited Publications
Cat. No.: HY-N1983
CAS No.: 38395-02-7
Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .
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1
1 Cited Publications
Cat. No.: HY-113405
CAS No.: 641-77-0
Purity:  99.62%
21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD) .
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1 Cited Publications
Cat. No.: HY-N0581
CAS No.: 106644-33-1
Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .
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Cat. No.: HY-N2103
CAS No.: 191729-43-8
Tenacissoside G is a C21 steroidal glycoside . Tenacissoside G inhibits Src and NF-κB, downregulates the activities of PTN and P-gp, induces DNA damage and apoptosis in cancer cells, inhibits their proliferation and migration, and reverses the resistance of ovarian cancer cells to Paclitaxel (HY-B0015). Tenacissoside G inhibits the expression of iNOS, TNF-α, IL-6, MMP-3, and MMP-13, reduces type II collagen degradation, and alleviates articular cartilage damage. Tenacissoside G can be used in studies related to ovarian cancer, colorectal cancer, and osteoarthritis .
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Cat. No.: HY-N1375
CAS No.: 84745-94-8
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .
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Cat. No.: HY-W741510
CAS No.: 1882-82-2
Synonyms: 21-Desoxycortisone; NSC 38722
21-Deoxycortisone (21-Desoxycortisone; NSC 38722) is an endogenous C21 pregnane steroid metabolite. 21-Deoxycortisone is a substrate for 21-hydroxylation in calf adrenal glands and can be converted to Cortisone (HY-17461). 21-Deoxycortisone can be used for metabolism-related research .
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Cat. No.: HY-134126
CAS No.: 6064-90-0
Target:  

Others

Research Areas:  

Cardiovascular Disease Others

Methyl heneicosanoate is a saturated fatty acid methyl ester (C21:0) found in the oil of Bauhinia purpurea L. petals .
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Cat. No.: HY-N2102
CAS No.: 191729-44-9
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .
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Cat. No.: HY-N1983R
CAS No.: 38395-02-7
Caudatin (Standard) is the analytical standard of Caudatin (HY-N1983). This product is intended for research and analytical applications. Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .
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Cat. No.: HY-N0420S3
CAS No.: 79864-95-2
Synonyms: Wormwood acid-13C2
Butanedioic acid- 13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
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Cat. No.: HY-Z8245
CAS No.: 145-15-3
Synonyms: Progesterone EP impurity C
20b-Dihydroprogesterone (Compond III) is a C-21 steroid found in water beetles Cybister limbatus, C. tripunctatus and C. confuses .
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Cat. No.: HY-124486
CAS No.: 21170-34-3
Research Areas:  

Others

NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative .
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Cat. No.: HY-132271
CAS No.: 23214-93-9
Chloramphenicol 1-acetate (Compound Ⅲ) is a microbial transformation product of Chloramphenicol (HY-B0239) by Streptomyces coelicolor. Chloramphenicol 1-acetate is the major product of Chloramphenicol acetyltransferase I (CATI) by regioselective acetylation of C21 hydroxy groups in steroids .
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Cat. No.: HY-N0582
CAS No.: 106758-54-7
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .
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Cat. No.: HY-Y0383S2
CAS No.: 432028-02-9
Dimethyl terephthalate- 13C2-1 is 13C labeled Dimethyl terephthalate. Dimethyl terephthalate is a low toxicity, low volatility industrial chemical widely used in the production of polyester fibers and films .
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Cat. No.: HY-W779002
CAS No.: 261728-61-4
alpha-D-glucose-13C2-1 is a 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite.
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Cat. No.: HY-113405R
CAS No.: 641-77-0
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol (HY-113405). This product is intended for research and analytical applications. 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD) .
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Cat. No.: HY-N12720
CAS No.: 1800029-53-1
Cynanoside J is a C21 steroidal glycosides that can be obtained from Cynanchum taihangense. The IC50 values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .
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Cat. No.: HY-P10801
Synonyms: C46 peptide
Target:  

HIV

Research Areas:  

Infection

mC46 (C46) peptide is a membrane-associated fusion peptide inhibitor. mC46 peptide potently inhibits HIV-1 replication and entry. mC46 also inhibits CCR5-tropic, CXCR4-tropic, and dual-tropic HIVs, SIV, and SHIV .
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