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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
ScN2a
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "ScN2a" in MCE Product Catalog:
Target:
Research Areas:
ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM .
Cat. No.: HY-RS12529
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SCN2A Human Pre-designed siRNA Set A contains three designed siRNAs for SCN2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12530
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Scn2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scn2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12531
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Scn2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Scn2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177629
CAS No.: 2756001-75-7
Synonyms: PRAX-222
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Elsunersen (PRAX‑222) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen can be used in research related to epileptic encephalopathy [2].
Cat. No.: HY-W081348
CAS No.: 60798-06-3
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1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC50 values of 13 nM and 25 nM, respectively .
Cat. No.: HY-177629A
Synonyms: PRAX-222 sodium
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Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy [2].
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
Cat. No.: HY-RS12535
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Scn3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Scn3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12550
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Scn9a Rat Pre-designed siRNA Set A contains three designed siRNAs for Scn9a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177629B
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Elsunersen sodium scrambled negative control is a scrambled negative control for Elsunersen sodium (HY-177629A). Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy [2].
Cat. No.: HY-177629C
Research Areas:
FAM labled Elsunersen sodium refers to Elsunersen sodium (HY-177629A) tagged with the fluorescent dye FAM. Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy [2].
Cat. No.: HY-177629D
Research Areas:
Cy3 labled Elsunersen sodium refers to Elsunersen sodium (HY-177629A) tagged with the fluorescent dye Cy3 (HY-D0822). Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy [2].
Cat. No.: HY-107662R
CAS No.: 34320-83-7
Target:
TCS PrP Inhibitor 13 (Standard) is the analytical standard of TCS PrP Inhibitor 13 (HY-107662). This product is intended for research and analytical applications. TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
