1 Result for "

Spinacetin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Spinacetin" in MCE Product Catalog:

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Spinacetin
Spinacetin
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Cat. No.: HY-N10182
CAS No.: 3153-83-1
Category:  

Inula japonica Extract Flavonols Plant Flavonoids Compositae/Asteraceae Extract

Target:  

Histamine Receptor Syk Apoptosis Autophagy Phospholipase MAPKAPK2 (MK2) Akt NF-κB Calcium Channel Sirtuin AMPK mTOR TNF Receptor Interleukin Related

Spinacetin is an orally active flavonoid glycoside found in Inula japonica, with antioxidant and anti-inflammatory activities. Spinacetin inhibits major inflammatory signaling pathways such as Syk, MAPK, and NF-κB, and reduces Ca 2+-dependent release of allergic mediators. Spinacetin induces protective autophagy and enhances antioxidant defense by upregulating SIRT3/SIRT1/PGC-1α, activating AMPK, and inhibiting mTOR and NF-κB, thereby exerting anti-apoptotic, cardioprotective, bladder-protective, and hepatoprotective effects. Spinacetin alleviates Doxorubicin (HY-15142A)-induced cardiotoxicity and reduces Cyclophosphamide (HY-17420)-induced hemorrhagic cystitis. Spinacetin can be used in research on allergic reactions, cardiotoxicity, cystitis, and cadmium-aggravated hepatic ischemia .
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