21

GSK3368715

21 Publications Verification

Cat. No.: HY-128717

CAS No.: 1629013-22-4

Purity: 99.19%

Synonyms: EPZ019997

Target:

Histone Methyltransferase

Research Areas:

Cancer

GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

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21

GSK3368715 dihydrochloride

21 Publications Verification

Cat. No.: HY-128717A

CAS No.: 1628925-77-8

Purity: 99.96%

Synonyms: EPZ019997 dihydrochloride

Target:

Histone Methyltransferase

Research Areas:

Cancer

GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

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17

UNC1999

17 Cited Publications

Cat. No.: HY-15646

CAS No.: 1431612-23-5

Purity: 99.87%

Target:

Histone Methyltransferase Autophagy

Research Areas:

Cancer

UNC1999, a chemical probe, is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC₅₀s of <10 nM and 45 nM, repectively.

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11

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride

11 Cited Publications

Cat. No.: HY-W074143

CAS No.: 36309-88-3

Synonyms: [Ru(DPP)3]Cl2

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] ²⁺) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S₂O₈ ^2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research ^[2].

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10

Sardomozide

10 Cited Publications

Cat. No.: HY-13746

CAS No.: 149400-88-4

Synonyms: CGP 48664; SAM-486A

Target:

Apoptosis

Research Areas:

Cancer

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

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10

5'-Methylthioadenosine

10 Cited Publications

Cat. No.: HY-16938

CAS No.: 2457-80-9

Synonyms: 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine

Category:

Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis Parasite

5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis ^[2].

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9

FIDAS-5

9 Cited Publications

Cat. No.: HY-136144

CAS No.: 1391934-98-7

Purity: 98.46%

Target:

Methionine Adenosyltransferase (MAT)

Research Areas:

Cancer

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities .

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7

Poly(deoxyadenylic-thymidylic) acid sodium

7 Cited Publications

Cat. No.: HY-138646

CAS No.: 86828-69-5

Synonyms: Poly(dA:dT) sodium

Target:

Cyclic GMP-AMP Synthase STING

Research Areas:

Inflammation/Immunology

Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase ^[2] .

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6

L-Asparagine

6 Cited Publications

Cat. No.: HY-N0667

CAS No.: 70-47-3

Synonyms: (-)-Asparagine; Asn; Asparamide

Category:

Neurological Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Apoptosis DNA/RNA Synthesis

L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia ^[2] .

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6

L-Asparagine monohydrate

6 Cited Publications

Cat. No.: HY-W017443

CAS No.: 5794-13-8

Category:

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis DNA/RNA Synthesis

L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia ^[2] .

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4

4-Aminohippuric acid

4 Cited Publications

Cat. No.: HY-B1306

CAS No.: 61-78-9

Synonyms: p-Aminohippuric acid

Category:

Other Diseases Disease Research Fields

Target:

Others

4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) ^[2] .

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3

SAMS

3 Cited Publications

Cat. No.: HY-P0136

CAS No.: 125911-68-4

Target:

AMPK

Research Areas:

Metabolic Disease

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

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3

JQEZ5

3 Cited Publications

Cat. No.: HY-100846

CAS No.: 1913252-04-6

Purity: 98.14%

Target:

Histone Methyltransferase

Research Areas:

Cancer

JQEZ5 is a potent and selective EZH2 lysine methyltransferase inhibitor. JQEZ5 SAM-competitively inhibits polycomb repressive complex 2 (PRC2) with an IC₅₀ of 80 nM. JQEZ5 has anti-tumor effects .

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2

Ogremorphin

2 Cited Publications

Cat. No.: HY-154954

CAS No.: 352563-21-4

Purity: 99.13%

Synonyms: OGM; GPR68-IN-1; OGM-8345

Target:

GPR68 Ferroptosis

Research Areas:

Inflammation/Immunology Cancer

Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells ^[2] .

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2

YB-0158

2 Cited Publications

Cat. No.: HY-136541

CAS No.: 1144043-83-3

Purity: 99.80%

Synonyms: Wnt pathway inhibitor 2

Target:

Wnt Apoptosis

Research Areas:

Cancer

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities .

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2

Cerlapirdine

2 Cited Publications

Cat. No.: HY-14431

CAS No.: 925448-93-7

Purity: 98.84%

Synonyms: SAM-531; PF-05212365

Target:

5-HT Receptor

Research Areas:

Neurological Disease

Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has the potential for researching the Alzheimer's disease .

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1

pH Receptor Probe

1 Cited Publications

Cat. No.: HY-D1563

CAS No.: 312961-83-4

pH Receptor Probe is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. pH Receptor Probe has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. pH Receptor Probe has been used as a pH sensor of lysosomal compartments .

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