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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
452 Results for "
Stille coupling
" in MedChemExpress (MCE) Product Catalog:
Products (452)
452 Results for "Stille coupling" in MCE Product Catalog:
54
54 Publications Verification
Cat. No.: HY-B0445A
CAS No.: 20111-18-6
Synonyms: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
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8 Cited Publications
Synonyms: Maleimidocaproyl monomethylauristatin F
Research Areas:
McMMAF (Maleimidocaproyl monomethylauristatin F) is a drug-linker conjugate for ADCs, formed by coupling the potent microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with a maleimidocaproyl (mc) linker. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
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8 Cited Publications
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NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs .
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7 Cited Publications
Synonyms: 2-(Phosphonomethyl)pentanedioic acid
Target:
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2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases .
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7 Cited Publications
Cat. No.: HY-100788C
CAS No.: 373645-42-2
Synonyms: 2-(Phosphonomethyl)pentanedioic acid sodium
Target:
Research Areas:
2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases .
3
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3
3 Cited Publications
Cat. No.: HY-P2141A
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2
Target:
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Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide .
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2 Cited Publications
Cat. No.: HY-B0558
CAS No.: 22232-54-8
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Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
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2 Cited Publications
Synonyms: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride
1
1 Cited Publications
Cat. No.: HY-D2171A
1
1 Cited Publications
Cat. No.: HY-15933
CAS No.: 40567-80-4
1
1 Cited Publications
Cat. No.: HY-D2171
1
1 Cited Publications
Cat. No.: HY-161541
1
1 Cited Publications
Cat. No.: HY-30014
CAS No.: 348640-06-2
1
1 Cited Publications
Cat. No.: HY-P99205
CAS No.: 1020264-78-1
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1
1 Cited Publications
Cat. No.: HY-43869
CAS No.: 1703768-74-4
Synonyms: PSMA-617 Ligand-Linker Conjugate
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Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA) .
1
1 Cited Publications
Cat. No.: HY-W013151
CAS No.: 114932-60-4
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1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry .
1
1 Cited Publications
Cat. No.: HY-178234
CAS No.: 1892576-07-6
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LY237 is a potent GPR84 full agonist, with EC50 values of 0.189 nM and 0.07 nM in cAMP inhibition assay and calcium flux assay, respectively. LY237 binds to the amphipathic orthosteric pocket of GPR84, stabilizes the active conformation of the receptor, and promotes its coupling with Gαi protein. LY237 can be used in research related to ulcerative colitis, fibrotic diseases, non-alcoholic steatohepatitis, and acute respiratory distress syndrome .
1
1 Cited Publications
Cat. No.: HY-W036410
CAS No.: 13822-56-5
Synonyms: 3-Aminopropyltrimethoxysilane; APTMS
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Aminopropyltrimethoxysilane (3-Aminopropyltrimethoxysilane; APTMS) is an aminosilane coupling agent and self-assembled molecule that can form self-assembled monolayers or multilayers on the surfaces of silicon-based materials, platinum, pullulan (Viscosity (10%): 15-180 mPa.s) (HY-W145522), and magnesium alloys through silanization or amine-mediated adsorption, serving for surface functionalization and performance regulation. Aminopropyltrimethoxysilane is applicable in research related to biomedical materials, antibacterial materials, and corrosion protection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
